Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (06): 946-953. Previous Articles     Next Articles

Review

α-氨基膦酸(酯)不对称合成研究进展

张建锋a,b,崔占伟a,苗志伟*,a,b,陈茹玉*,a   

  1. (a南开大学元素有机化学研究所 天津 300071)
    (b清华大学生命有机磷化学及化学生物学教育部重点实验室 北京 100084)
  • 收稿日期:2007-01-13 修回日期:2007-10-19 发布日期:2008-06-26
  • 通讯作者: 苗志伟

Recent Progress in Asymmetric Synthesis of α-Aminophosphonic Acid and α-Aminophosphonates

ZHANG Jian-Fenga,b, CUI Zhan-Weia, MIAO Zhi-Wei*,a,b, CHEN Ru-Yu*,a   

  1. (a State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry,
    Nankai University, Tianjin 300071)
    (b Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education,
    Tsinghua University, Beijing 100084)
  • Received:2007-01-13 Revised:2007-10-19 Published:2008-06-26
  • Contact: MIAO Zhi-Wei

As the isosteric or bio-isosteric analogues of the corresponding α-amino acids, α-aminophosphonic acids have diverse and interesting biological and biochemical properties. This article reviews the recent studies on the asymmetric synthesis of optically active α-aminophosphonic acids and α-aminophosphonates both by chiral auxiliary induced and chiral catalyst catalysed methods.

Key words: optical activity, asymmetric synthesis, α-aminophosphonic acid