Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (07): 1138-1144. Previous Articles     Next Articles

Review

Ni(II)螯合物在氨基酸合成中的应用

王江a;邓光辉a;柳红*a;蒋华良a,b

  

  1. a中国科学院上海药物研究所新药研究国家重点实验室药物设计和发现中心 上海 201203
    b华东理工大学药学院 上海 200237
  • 收稿日期:2007-08-17 修回日期:2007-12-12 发布日期:2008-07-28
  • 通讯作者: 柳红

Application of Ni(II) Chelate to Amino Acid Synthesis

WANG, Jianga;DENG, Guang-Huia;LIU, Hong*,a;JIANG, Hua-Lianga,b   

  1. a Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai
    Institute of Materia Medica,
    Chinese Academy of Sciences, Shanghai 20120

    b School of Pharmacy, East China University of Science and Technology, Shanghai 200237

  • Received:2007-08-17 Revised:2007-12-12 Published:2008-07-28
  • Contact: Liu Hong

Synthesis of amino acids via Ni(II) chelate plays an important role in amino acid
preparations. This article reviews the recent progress of this methodology, metal ion
selection, chiral ligand improvement, halide optimization and various kinds of non-natural
amino acid preparation in detail.

Key words: amino acid synthesis, asymmetric synthesis, Ni(II) chelate