Three-Component One-Pot Synthesis of 1,6-Dioxa-5-oxo-1,4,5,6- tetrahydrophenanthrene Derivatives in Aqueous Media

Abstract

2-Amino-4-aryl-3-cyano-1,6-dioxa-5-oxo-1,4,5,6-tetrahydrophenanthrenes were synthesized by a three-component reaction of aromatic aldehydes, malononitrile and 4-hydroxycoumarin using triethylbenzylammonium chloride as catalyst in aqueous media. The reaction has the advantages of good yields, less pollution, simple operation and environmental friendliness.

Key words: one-pot synthesis, three-component, aqueous media, 1,6-dioxa-5-oxo-1,4,5,6-tetrahydrophenanthrene

Cite this article

SHI Da-Qing*^,1,2,WANG Jing^1,3,ZHUANG Qi-Ya^1,2,WANG Xiang-Shan^1,2. Three-Component One-Pot Synthesis of 1,6-Dioxa-5-oxo-1,4,5,6- tetrahydrophenanthrene Derivatives in Aqueous Media[J]. Chin. J. Org. Chem., 2006, 26(05): 643-647.

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水介质中1,6-二氧-5-氧代-1,4,5,6-四氢化菲衍生物的三组分一锅合成