Synthesis of Novel 5-Fluorouracil Derivatives Containing Amino Acid Schiff Base and Their Antitumor Activities

Abstract

In order to search for novel high activity and low toxicity antitumor drugs, thirteen novel 5-fluorouracil derivatives containing amino acid Schiff base were synthesized via the condensation reactions of N1-(2-furanidyl)-N3-(4-bromobutyl)-5-fluorouracil and amino acid Schiff bases. The structures of the products were confirmed by IR, ¹H NMR, MS spectra and elemental analyses. The result of preliminary bioassay shows that the new compounds possess antitumor activities to some extent.

Key words: 5-fluorouracil, antitumor activity, amino acid Schiff base

Cite this article

SHI De-Qing*,CHEN Qi,LI Zhong-Hua. Synthesis of Novel 5-Fluorouracil Derivatives Containing Amino Acid Schiff Base and Their Antitumor Activities[J]. Chin. J. Org. Chem., 2005, 25(05): 549-553.

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