One-Pot Synthesis of 2-Amino-6-bromo-4-(substituted phenyl)-5H- indeno[1,2-b]pyridine-3-carbonitrile De-rivatives under Microwave Irradiation

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (02): 233-237. Previous Articles Next Articles

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微波辐射下一锅法合成2-氨基-6-溴-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物

季春香¹，薛永震²，王建强¹，殷俊¹，崔永涛¹，郭成*^,1

(¹南京工业大学理学院南京 210009)
(²南京化工研究院南京 210033)

收稿日期:2009-02-16 修回日期:2009-05-18 发布日期:2010-03-30
通讯作者: 郭成 E-mail:guocheng@njut.edu.cn

One-Pot Synthesis of 2-Amino-6-bromo-4-(substituted phenyl)-5H- indeno[1,2-b]pyridine-3-carbonitrile De-rivatives under Microwave Irradiation

Ji Chunxiang¹ Xue Yongzhen² Wang Jian-qiang¹ Yin Jun¹ Cui Yongtao¹ Guo Cheng*^,1

(¹College of Sciences, Nanjing University of Technology, Nanjing 210009)
(²Nanjing Institute of Chemical Industry, Nanjing 210033)

Received:2009-02-16 Revised:2009-05-18 Published:2010-03-30
Contact: Cheng Guo E-mail:guocheng@njut.edu.cn

Abstract

Seven new 2-amino-6-bromo-4-(substituted phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile derivatives were synthesized by using benzaldehydes, 4-bromo-indan-1-one and malononitrile in one-pot via conventional heating and microwave irradiation techniques. By comparison of the two methods, the microwave irradiation possessed such advantages as short reaction time, high yields and so on over the conventional method under normal pressure. The structures of these compounds were characterized by IR, ¹H NMR spectra and elemental analysis.

Key words: 4-bromo-indanone, microwave irradiation, indeno[1,2-b]pyridine, conventional heating

Cite this article

JI Chun-Xiang, XUE Yong-Shen, WANG Jian-Jiang, YAN Dun, CUI Yong-Chao, GUO Cheng. One-Pot Synthesis of 2-Amino-6-bromo-4-(substituted phenyl)-5H- indeno[1,2-b]pyridine-3-carbonitrile De-rivatives under Microwave Irradiation[J]. Chin. J. Org. Chem., 2010, 30(02): 233-237.

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微波辐射下一锅法合成2-氨基-6-溴-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物

One-Pot Synthesis of 2-Amino-6-bromo-4-(substituted phenyl)-5H- indeno[1,2-b]pyridine-3-carbonitrile De-rivatives under Microwave Irradiation

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