Green Synthesis of the Adrenomimetic Drug Methoxamine Hydro-chloride

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (02): 282-284. Previous Articles Next Articles

Notes

拟肾上腺素药盐酸甲氧明的绿色合成

谢宇*，胡金刚，贾杰，洪小伟，魏娅

(南昌航空大学环境与化学工程学院南昌 330063)

收稿日期:2009-02-25 修回日期:2009-08-04 发布日期:2010-02-20

Green Synthesis of the Adrenomimetic Drug Methoxamine Hydro-chloride

Xie Yu* Hu Jingang Jia Jie Hong Xiaowei Wei Ya

(School of Environmental and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063)

Received:2009-02-25 Revised:2009-08-04 Published:2010-02-20

Abstract

Methoxamine hydrochloride was synthesized from p-dihydroxybenzene by O-methylation, Friedel-Crafts acylation, oximation reaction, oxime reduction and keto-amine hydrogenation reactions. All intermediates and products were characterized by IR, ¹H NMR spectra and elemental analysis. The total yield was 37.6%. Compared to the traditional synthetic procedures of methoxamine hydrochloride, the procedures were temperate, convenient, economical, high-yielding and environment-friendly.

Key words: methoxamine, methylation, oximation, reduction, green synthesis

Cite this article

XIE Yu, HU Jin-Gang, GU Jie, HONG Xiao-Wei, WEI Ya. Green Synthesis of the Adrenomimetic Drug Methoxamine Hydro-chloride[J]. Chin. J. Org. Chem., 2010, 30(02): 282-284.

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拟肾上腺素药盐酸甲氧明的绿色合成

Green Synthesis of the Adrenomimetic Drug Methoxamine Hydro-chloride

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