Synthesis of Benzodiazepinonic Acid and Application in  Peptide Mimetics

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (07): 1010-1016. Previous Articles Next Articles

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苯并二氮杂酮酸的合成及其在肽模拟中的应用

袁建海，杨潇骁，林浩，王德心*

(北京协和医学院中国医学科学院药物研究所北京 100050)

收稿日期:2009-11-06 修回日期:2010-01-06 发布日期:2010-02-03
通讯作者: 王德心 E-mail:wangdx@imm.ac.cn

Synthesis of Benzodiazepinonic Acid and Application in Peptide Mimetics

YUAN Jian-Hai, YANG Xiao-Xiao, LIN Hao, WANG De-Xin*

(Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100050)

Received:2009-11-06 Revised:2010-01-06 Published:2010-02-03

Abstract

To synthesize two 1,4-benzodiazepine-2,5-dione intermediates and with free carboxyl, two methods were applied in this paper, in which isatoic acid was used as starting material and reacted with glutamic acid (L-Glu) and imino diacetic acid (Ida), respectively. Meanwhile, peptide mimetics ～, , , ～, , with 1,4-benzodiazepine-2,5-dione cycle were prepared by condensation of or with amino components ～, and . In addition, effect on the microwave-assisted synthesis of 1,4-benzodiazepine-2,5-dionic acid by solvent was discussed. All the new compounds were characterized by MS and H NMR techniques.

Key words: isatoic acid, 1,4-benzodiazepine-2,5-dionic acid, peptide mimetics, microwave

Cite this article

YUAN Jian-Hai, YANG Xiao-Xiao, LIN Hao, WANG De-Xin. Synthesis of Benzodiazepinonic Acid and Application in Peptide Mimetics[J]. Chin. J. Org. Chem., 2010, 30(07): 1010-1016.

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苯并二氮杂酮酸的合成及其在肽模拟中的应用

Synthesis of Benzodiazepinonic Acid and Application in Peptide Mimetics

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