Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (08): 1175-1179. Previous Articles     Next Articles

Full Papers

奥利司他的合成新路线

徐勤耀,俞蒋辉,胡文浩,杨琍苹   

  1. (华东师范大学化学系 上海 200062)
  • 收稿日期:2009-11-24 修回日期:2010-01-19 发布日期:2010-03-04
  • 通讯作者: 杨琍苹 E-mail:lpyang@chem.ecnu.edu.cn
  • 基金资助:

    上海市科学技术委员会基金(No. 07dz22005)资助项目;国家级.国家自然科学基金

A New Route for the Preparation of Orlistat

XU Qin-Yao, YU Jiang-Hui, HU Wen-Hao, YANG Li-ping   

  1. (Department of Chemistry, East China Normal University, Shanghai 200062)
  • Received:2009-11-24 Revised:2010-01-19 Published:2010-03-04

A new route for the total synthesis of orlistat is reported. Mukaiyama-aldol reaction, Noyori reduction and Frater-Seebach alkylation were used to construct three key chiral cernters in the side chain of orlistat.

Key words: orlistat, tetrahydrolipstatin, Mukaiyama-aldol reaction, Noyori reduction reaction, Frater- Seebach alkylation reaction, asymmetric synthesis