Study on the Chemical Constituents from the Latex of Antiaris toxicaria

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (04): 533-537. Previous Articles Next Articles

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见血封喉乳汁中的化学成分研究

梅文莉，干玉娟，阙东枚，李小娜，戴好富*

(中国热带农业科学院热带生物技术研究所农业部热带作物生物技术重点开放实验室海口 571101)

收稿日期:2010-08-18 修回日期:2010-10-25 发布日期:2010-12-06
通讯作者: 戴好富 E-mail:hfdai@yahoo.cn

Study on the Chemical Constituents from the Latex of Antiaris toxicaria

MEI Wen-Li, GAN Yu-Juan, QUE Dong-Mei, LI Xiao-Na, DAI Hao-Fu

(Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101)

Received:2010-08-18 Revised:2010-10-25 Published:2010-12-06

Abstract

Six compounds were isolated from the ethanol extract of the latex of Antiaris toxicaria (Pers.) Lesch collected in Hainan. The structures were established as toxicarioside I (1), strophanthidin (2), periplogenin (3), (3β,5α,14β,17α)-3,14-dihydroxypregnan-20-one (4), α-tocopherol (5) and 3,4,5-trimethoxy- phenol (6) by spectroscopic methods (IR, 1D-, 2D-NMR and HR-ESIMS). Among them, compound 1 was a new cardenolide, compounds 4 and 5 were isolated from this plant for the first time. Compounds 1～3 showed cytotoxic effects on chronic myelogenous leukemia (K562), human gastric carcinoma (SGC-7901) and human hepatoma (SMMC-7721) cell lines with IC₅₀ values ranged from 0.001 to 12.3 μmol•L^－1.

Key words: Antiaris toxicaria, cardenolide, toxicarioside I, cytotoxicity

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MEI Wen-Li, GAN Yu-Juan, QUE Dong-Mei, LI Xiao-Na, DAI Hao-Fu. Study on the Chemical Constituents from the Latex of Antiaris toxicaria[J]. Chin. J. Org. Chem., 2011, 31(04): 533-537.

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见血封喉乳汁中的化学成分研究

Study on the Chemical Constituents from the Latex of Antiaris toxicaria

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