One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles under microwave irradiation without the catalyst

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (06): 860-864. Previous Articles Next Articles

Notes

无催化剂条件下微波辐射一步法合成2-氨基-4-芳基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-腈

栾长军¹，王建强¹，张国华¹，王伟¹，唐拾贵²，郭成*^,1

(¹南京工业大学理学院南京 210009)
(²南京工业大学生物与制药工程学院南京 210009)

收稿日期:2010-08-10 修回日期:2010-10-10 发布日期:2011-01-11
通讯作者: 郭成 E-mail:guocheng@njut.edu.cn

One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles under microwave irradiation without the catalyst

Luan Changjun¹ Wang Jianqiang¹ Zhang Guo-hua¹ Wang Wei¹ Tang Shigui² Guo Cheng*^,1

(¹College of Science, Nanjing University of Technology, Nanjing 210009)
(² Biotechnology and Pharmaceutical Engineering, Nanjing University of Technol-ogy, Nanjing 210009)

Received:2010-08-10 Revised:2010-10-10 Published:2011-01-11
Contact: Cheng Guo E-mail:guocheng@njut.edu.cn

A series of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives (4a～4g) were prepared by using 1,3-cyclohexanedione, aromatic aldehydes and malononitrile in anhydrous alcohol under microwave irradiation without catalyst. Compared with conven-tional heating method, the method of microwave irradiation possesses advantages including short time, high yield and environmental friendliness, etc. The structures of these compounds were characterized by IR, ¹H NMR spectra and elemental analysis.

Key words: aromatic aldehyde, malononitrile, 1,3-cyclohexanedione, benzopyran, microwave irradiation

Cite this article

LUAN Chang-Jun, WANG Jian-Qiang, ZHANG Guo-Hua, WANG Wei, TANG Shi-Gui, GUO Cheng. One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles under microwave irradiation without the catalyst[J]. Chin. J. Org. Chem., 2011, 31(06): 860-864.

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无催化剂条件下微波辐射一步法合成2-氨基-4-芳基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-腈

One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles under microwave irradiation without the catalyst

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