Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (08): 1266-1271. Previous Articles     Next Articles

Notes

含嘧啶氨基的三取代三嗪衍生物的合成及其抗菌、抗肿瘤活性研究

陈华*,1,谷云景1,苑香果1,赵莲1,赵建鹏1,秦占斌1,刘丽2,李小六*,1,曹克强2,张金超1   

  1. (1河北大学化学与环境科学学院 河北省化学生物学重点实验室 保定 071002)
    (2河北农业大学植物保护学院 保定 071001)
  • 收稿日期:2011-01-11 修回日期:2011-03-12 发布日期:2011-03-12
  • 通讯作者: 陈华 E-mail:hua-todd@163.com

Synthesis and Antifungal, Anti-tumor Studies of the Trisubstitued Triazines Bearing Aminopyrimidine Group

Chen Hua*,1 Gu Yunjing1 Yuan Xiang-guo1 Zhao Lian1 Zhao Jianpeng1 Qin Zhanbin1 Liu Li2 Li Xiaoliu*,1 Cao Keqiang2 Zhang Jinchao1   

  1. (1 Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002)
    (2 College of Plant Protec-tion, Hebei Agricultural University, Baoding 071001)
  • Received:2011-01-11 Revised:2011-03-12 Published:2011-03-12

A series of novel trisubstituted 1,3,5-triazine compounds bearing aminopyrimidine group were synthesized using cyanuric chloride as the starting material. The antifungal activitiy against Valsa mali and antiproliferative activity for three tumor cells of all the triazine compounds were evaluated. The results showed that a majority of the compounds 2aa2cb and 3aa3cb have notable inhibitory activity against Valsa mali. Some compounds, such as 4ba and 4ca, showed good cytotoxicity to BGC-823 and Hela tumor cells with the IC50 value of 10.9 and 11.3 μmol/L, respectively, higher than that of the positive control cisplatin.

Key words: aminopyrimidine, triazine, antifungal activity, anti-tumor activity