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Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (11): 1943-1948. Previous Articles     Next Articles

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新型含2-取代-1,3-噻唑烷环的噻唑酰胺类化合物的合成与生物活性研究

戴红*1,2，刘建兵1，苗文科1，吴珊珊1，张欣1，王婷婷1，方建新*1   

  1. (1南开大学元素有机化学国家重点实验室 天津 300071)
    (2南通大学化学化工学院 南通 226019)
  • 收稿日期:2011-06-30 修回日期:2011-08-26 发布日期:2011-09-06
  • 通讯作者: 方建新 E-mail:fjx@nankai.edu.cn
  • 基金资助:

    国家自然科学基金

Synthesis and Bioactivities of Novel Thiazole Amide Derivatives Containing a 2-Substituted-1,3-thiazolidine Ring

Dai Hong*1,2 Liu Jianbing1 Miao Wenke1 Wu Shanshan1 Zhang Xin1, Wang Tingting1 Fang Jianxin*1   

  1. (1 State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071)
    (2 College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019)
  • Received:2011-06-30 Revised:2011-08-26 Published:2011-09-06
  • Contact: jianxin fang E-mail:fjx@nankai.edu.cn

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In order to find novel thiazole-heterocycle lead compounds, nineteen new thiazole amides 4 containing 2-substituted-1,3-thiazolidine were synthesized from a condensation reaction of 2-cyanoimino-3- (2-aminothiazol-4-ylmethyl)thiazolidine with substituted benzoyl chlorides (or acetyl chloride). The structures of these compounds were confirmed by 1H NMR spectra and elemental analysis. The structure of 4s was further characterized by MS technique. The structure of 4a was also determined by X-ray diffraction analysis. Biological activities of the title compounds was tested, and some compounds displayed certain fungicidal and plant growth regulatory activities.

Key words: 2-substituted-1,3-thiazolidine, thiazole, amide, synthesis, bioactivity