Microwave-Assisted Synthesis of 2-Substituted-4,5-diarylimidazoles from Benzoin Carboxylate Derivatives under Solvent-Free Conditions

doi:10.6023/cjoc1201101

Abstract

Benzoin carboxylate derivatives were synthesized with the aromatic aldehydes as raw material in the presence of the catalyst VB₁. And then, benzoin carboxylate derivatives reacted with different acylating reagents under mild reaction conditions, and benzoin carboxylates were obtained. Further, 2-substituted-4,5-di(aryl)imidazoles were produced from benzoin carboxylates in the presence of solid supports Al₂O₃ under solvent-free and microware assisted condition, and seven of them have not been reported. The reaction possessed many advantages such as mild reaction conditions, short reaction time, and no organic solvents consumed. Therefore, it is a facile and efficient synthetic method. Moreover, the synthesized compounds were characterized by ¹H NMR, ¹³C NMR, IR, HRMS techniques.

Key words: 2-substituted-4,5-di(aryl)imidazoles, benzoin carboxylates, microwave-assisted synthesis, solid-support, solvent-free, esterification

Cite this article

Li Baozhi, Gu Qiang, Zhao Tianqi, He Yuanhui, Tong Yanan, Zhang Yumin. Microwave-Assisted Synthesis of 2-Substituted-4,5-diarylimidazoles from Benzoin Carboxylate Derivatives under Solvent-Free Conditions[J]. Chin. J. Org. Chem., 2012, 32(08): 1459-1467.

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