Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (08): 1769-1773.DOI: 10.6023/cjoc201301066 Previous Articles     Next Articles

Articles

多聚赖氨酸的合成及其微结构对pH的响应

吴生蓉, 耿欣, 陈才, 蔡亦康, 韩国志   

  1. 南京工业大学理学院 南京 210009
  • 收稿日期:2013-01-25 修回日期:2013-03-15 发布日期:2013-04-09
  • 通讯作者: 韩国志 E-mail:han@njut.edu.cn
  • 基金资助:

    中国博士后基金(No. 20100481084)资助项目.

Synthesis of Poly-L-lysine and Its Structural Response to Environmental pH

Wu Shengrong, Geng Xin, Chen Cai, Cai Yikang, Han Guozhi   

  1. College of Science, Nanjing University of Technology, Nanjing 210009
  • Received:2013-01-25 Revised:2013-03-15 Published:2013-04-09
  • Supported by:

    Project supported by the Postdoctoral Foundation of China (No. 20100481084).

Using L-lysine as raw material, Polylysine (PLL) was synthesized through four steps. The structures of intermediums and the final product were confirmed by IR and 1H NMR. Furthermore, some key synthetic steps were optimized in the process. On the basis, response ability to environmental pH of PLL structures was investigated by SEM and circular dichroism spectra. Experimental results indicated that polypeptide structure of PLL has good response ability to pH of environment. Under different pH conditions, distinct morphology was formed. Under acidic conditions, PLL presented a specific coil conformation, whereas orderly pine needle was observed under alkaline conditions.

Key words: polylysine, N-carboxy-(Nε-benzyloxycarbonyl)-L-lysine anhydride (NCA), synthesis, pH, response