Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (9): 1988-1993.DOI: 10.6023/cjoc201304028 Previous Articles     Next Articles

Notes

N-亚苄基橙皮素腙及类似物的合成与细胞活性

刘志平a,b, 韦万兴a, 甘春芳b, 黄燕敏b, 刘盛a, 周敏a, 崔建国b   

  1. a 广西大学化学化工学院 南宁 530004;
    b 广西师范学院化学与生命科学学院 南宁 530001
  • 收稿日期:2013-04-18 修回日期:2013-05-22 发布日期:2013-05-31
  • 通讯作者: 韦万兴 E-mail:chewxwei@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(No. 81060261);广西科学自然科学基金重点(No. 2011jjD20002)资助项目

Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues

Liu Zhipinga,b, Wei Wanxinga, Gan Chunfangb, Huang Yanminb, Liu Shenga, Zhou Mina, Cui Jianguob   

  1. a College of Chemistry and Chemical Engineer, Guangxi University, Nanning 530004;
    b College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001
  • Received:2013-04-18 Revised:2013-05-22 Published:2013-05-31
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81060261) and the Natural Science Foundation of Guangxi Province (No. 2011jjD20002)

Hesperitin hydrazone (2) was generated by the reaction of natural hesperitin (1) as raw material with hydrazine hydrate. Eight N-benzylidene hesperitin hydrazones 310 and six analogues 1116 were synthesized by the reaction of 2 with various aldehydes, respectively. The structures of all reaction products were confirmed by NMR, IR and HR-MS techniques. And the cytotoxity against human cancer cell SGC-7901 of the synthesized compounds was also evaluated. The results showed 5, 7, 10 and 16 exhibiting distinct cytotoxity against SGC-7901.

Key words: hesperitin, hesperitin hydrazones, N-benzylidene, cytotoxicity