Synthetic Progress of Indoxamycin Family

doi:10.6023/cjoc201501002

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (4): 760-769.DOI: 10.6023/cjoc201501002 Previous Articles Next Articles

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Indoxamycin家族分子的合成研究进展

何驰, 丁寒锋

浙江大学化学系杭州 310028

收稿日期:2015-01-05 修回日期:2015-02-03 发布日期:2015-01-05
通讯作者: 丁寒锋 E-mail:hfding@zju.edu.cn
基金资助:
国家自然科学基金(Nos. 21472167, 21202144)、新博士点教师基金(No. 20120101120087)资助项目.

Synthetic Progress of Indoxamycin Family

He Chi, Ding Hanfeng

Department of Chemistry, Zhejiang University, Hangzhou 310028

Received:2015-01-05 Revised:2015-02-03 Published:2015-01-05
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21472167, 21202144) and the Research Fund For the Doctoral Program of Higher Education of China (No. 20120101120087).

Indoxamycins A～F represent a novel class of polyketides isolated from the salin cultures of actinomycetes, which contain a common sterically congested [5,5,6] tricyclic cage-like structure featuring six contiguous stereogenic centers. Indoxamycins A and F were reported to exhibit significant growth-inhibition activity against HT-29 tumor cell lines. This review summarizes the synthetic progress towards indoxamycin family members both by the Carreira and Ding groups.

Key words: indoxamycins, enynes, rearrangement, tandem reaction, total synthesis

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He Chi, Ding Hanfeng. Synthetic Progress of Indoxamycin Family[J]. Chin. J. Org. Chem., 2015, 35(4): 760-769.

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Indoxamycin家族分子的合成研究进展

Synthetic Progress of Indoxamycin Family

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