Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides

doi:10.6023/cjoc201502010

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1917-1922.DOI: 10.6023/cjoc201502010 Previous Articles Next Articles

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铜催化的芳基酮及其衍生物氧化酰胺化合成α-酮酰胺的反应研究

龚久涵, 朱正, 卢林, 郭生梅, 蔡琥

南昌大学化学学院南昌 330031

收稿日期:2015-02-07 修回日期:2015-05-12 发布日期:2015-05-26
通讯作者: 郭生梅, 蔡琥 E-mail:smguo@ncu.edu.cn;caihu@ncu.edu.cn
基金资助:
科技部973计划(No. 2012CBA01204)和国家自然科学基金(No. 21302084)资助项目.

Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides

Gong Jiuhan, Zhu Zheng, Lu Lin, Guo Shengmei, Cai Hu

College of chemistry, Nanchang University, Nanchang 330031

Received:2015-02-07 Revised:2015-05-12 Published:2015-05-26
Supported by:
Project supported by the National Key Basic Research Program of Ministry of Science and Technology of China (No. 2012CBA01204) and the National Natural Science Foundation of China (No. 21302084).

1. Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides.PDF(4694KB)

Abstract

The oxidative amidation between aryl ketone and amine to form keto amide in water was studied. A variety of amides co-catalyzed by copper and iodine were efficiently synthesized using TBHP as an oxidant under room temperature. On the other hand, a copper-catalyzed C—C bond cleavage of β-keto ester and its derivatives to prepare α-keto amides under O₂ atmosphere was also studied.

Key words: H₂O, O₂, aryl ketone, β-keto esters, α-keto amides

Cite this article

Gong Jiuhan, Zhu Zheng, Lu Lin, Guo Shengmei, Cai Hu. Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides[J]. Chin. J. Org. Chem., 2015, 35(9): 1917-1922.

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铜催化的芳基酮及其衍生物氧化酰胺化合成α-酮酰胺的反应研究

Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides

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