Basic Ionic Liquid Mediated One-Pot Synthesis of 4-Aminobenzylidene-Scaffold Derivatives

doi:10.6023/cjoc201505012

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1910-1916.DOI: 10.6023/cjoc201505012 Previous Articles Next Articles

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碱性离子液体催化的一锅法合成4-氨基苯乙烯衍生物

徐辉, 桂奇飞, 谌志华, 曲浩然, 虞心红

华东理工大学药学院上海 200237

收稿日期:2015-05-06 修回日期:2015-05-21 发布日期:2015-05-29
通讯作者: 虞心红 E-mail:xhyu@ecust.edu.cn
基金资助:
国家自然科学基金(Nos. 21476078, 20972051)资助项目.

Basic Ionic Liquid Mediated One-Pot Synthesis of 4-Aminobenzylidene-Scaffold Derivatives

Xu Hui, Gui Qifei, Chen Zhihua, Qu Haoran, Yu Xinhong

School of Pharmacy, East China University of Science and Technology, Shanghai 200237

Received:2015-05-06 Revised:2015-05-21 Published:2015-05-29
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21476078, 20972051).

1. Basic Ionic Liquid Mediated One-Pot Synthesis of 4-Aminobenzylidene-Scaffold Derivatives.PDF(1753KB)

Abstract

4-Aminobenzylidene derivatives are very important synthetic intermediates. A fast and green protocol for the one-pot multi-component reaction of 4-halobenzaldehyde, active methylene compounds and secondary amines was developed using a basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmIm]OH, as catalyst, reagent and reaction medium. All the corresponding 4-aminobenzylidene-scaffold derivatives were obtained in good to excellent yields. The [bmIm]OH could be reused. Moreover, the structures of all the products were confirmed by ¹H NMR, ¹³C NMR and MS techniques.

Key words: ionic liquid, multi-component reaction, 4-aminobenzylidene

Cite this article

Xu Hui, Gui Qifei, Chen Zhihua, Qu Haoran, Yu Xinhong. Basic Ionic Liquid Mediated One-Pot Synthesis of 4-Aminobenzylidene-Scaffold Derivatives[J]. Chin. J. Org. Chem., 2015, 35(9): 1910-1916.

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碱性离子液体催化的一锅法合成4-氨基苯乙烯衍生物

Basic Ionic Liquid Mediated One-Pot Synthesis of 4-Aminobenzylidene-Scaffold Derivatives

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