Synthesis, Characterization and Antitumour Activity of Diorganotin (IV) Complexes Containing Silicon of 2-Mercaptobenzothiazole

doi:10.6023/cjoc201503002

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1923-1928.DOI: 10.6023/cjoc201503002 Previous Articles Next Articles

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含硅二烃基锡(IV)的2-巯基苯并噻唑配合物的合成、结构及抗癌活性

廖启华^a, 林森^a, 邓瑞红^a, 黄志强^a, 邓柯玉^b, 严兆华^a

a 南昌大学化学系南昌 330031;
b 南昌大学医学院南昌 330031

收稿日期:2015-03-03 修回日期:2015-05-20 发布日期:2015-05-26
通讯作者: 林森 E-mail:senlin@ncu.edu.cn
基金资助:
国家自然科学基金(No. 20762006)资助项目.

Synthesis, Characterization and Antitumour Activity of Diorganotin (IV) Complexes Containing Silicon of 2-Mercaptobenzothiazole

Liao Qihua^a, Lin Sen^a, Deng Ruihong^a, Huang Zhiqiang^a, Deng Keyu^b, Yan Zhaohua^a

a Department of Chemistry, Nanchang University, Nanchang 330031;
b School of Medicine, Nanchang University, Nanchang 330031

Received:2015-03-03 Revised:2015-05-20 Published:2015-05-26
Supported by:
Project supported by the National Natural Science Foundation of China (No. 20762006).

1. Synthesis, Characterization and Antitumour Activity of Diorganotin (IV) Complexes Containing Silicon of 2-Mercaptobenzothiazole.PDF(2824KB)

Abstract

Six diorganotin(IV) complexes containing silicon of 2-mercaptobenzothiazole R¹R²Sn(L)₂ (R¹＝Me₃SiCH₂, R²＝Me₃SiCH₂ or Ph, Cy; R¹＝EtMe₂SiCH₂, R²＝EtMe₂SiCH₂ or Ph, Cy. LH＝2-mercaptobenzothiazole) have been synthesized and characterized by ¹H NMR, ¹³C NMR, IR, elemental analysis and X-ray single-crystal study. The results showed that ligand L acts as thiol tautomerism coordinating with tin atom, and thus the central tin atom was six coordinated in distorted octahedral geometry. The preliminary bioassay tests showed that diorganotin complexes of 2-mercaptobenzothiazole have a good antitumor activity in vitro against A-549.

Key words: diorganotin, 2-mercaptobenzothiazole, complexes, synthesis, structure, antitumour activity

Cite this article

Liao Qihua, Lin Sen, Deng Ruihong, Huang Zhiqiang, Deng Keyu, Yan Zhaohua. Synthesis, Characterization and Antitumour Activity of Diorganotin (IV) Complexes Containing Silicon of 2-Mercaptobenzothiazole[J]. Chin. J. Org. Chem., 2015, 35(9): 1923-1928.

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含硅二烃基锡(IV)的2-巯基苯并噻唑配合物的合成、结构及抗癌活性

Synthesis, Characterization and Antitumour Activity of Diorganotin (IV) Complexes Containing Silicon of 2-Mercaptobenzothiazole

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