Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives

doi:10.6023/cjoc201510010

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (4): 838-843.DOI: 10.6023/cjoc201510010 Previous Articles Next Articles

ARTICLE

琼脂糖水凝胶包埋柠檬酸三钠催化多组分反应合成苯并吡喃及吡喃并吡唑衍生物

李志鹏, 陈斐然, 王东阳, 黄杏甜, 李毅群

暨南大学化学系广州 510632

收稿日期:2015-10-11 修回日期:2015-11-25 发布日期:2015-12-07
通讯作者: 李毅群 E-mail:tlyq@jnu.edu.cn
基金资助:
国家自然科学基金(Nos.21372099,21072077)和广东省自然科学基金(No.10151063201000051,8151063201000016)资助项目.

Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives

Li Zhipeng, Chen Feiran, Wang Dongyang, Huang Xingtian, Li Yiqun

Department of Chemistry, Jinan University, Guangzhou 510632

Received:2015-10-11 Revised:2015-11-25 Published:2015-12-07
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21372099, 21072077), the Guangdong Natural Science Foundation (Nos. 10151063201000051, 8151063201000016).

1. Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives.PDF(1260KB)

Abstract

An efficient method for the synthesis of benzopyran derivatives and pyrano[2,3-c]pyrazole derivatives via multicomponent reaction in the presence of agarose hydrogel entrapped trisodium citrate (gel-citrate) as catalyst is developed. The protocol presented here has the merits of easy preparation and handling of catalyst, environmentally benign, simple operation and convenient workup, and excellent yields. Moreover, the catalyst could be recovered and reused at least 6 cycles without apparently losing its activities.

Key words: agarose, hydrogel-entrapped catalyst, benzopyran, pyrano[2,3-c]pyrazole, multicomponent reaction

Cite this article

Li Zhipeng, Chen Feiran, Wang Dongyang, Huang Xingtian, Li Yiqun. Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives[J]. Chin. J. Org. Chem., 2016, 36(4): 838-843.

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琼脂糖水凝胶包埋柠檬酸三钠催化多组分反应合成苯并吡喃及吡喃并吡唑衍生物

Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives

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