Advances in Development of Chiral Sensors

doi:10.6023/cjoc201805042

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 2927-2936.DOI: 10.6023/cjoc201805042 Previous Articles Next Articles

Special Issue: 荧光探针-生物传感合辑；有机超分子化学合辑

Reviews

手性传感器研究进展

熊斐, 李莉

中国医学科学院&北京协和医学院药物研究所活性物质发现与适药化研究北京市重点实验室北京 100050

收稿日期:2018-05-20 修回日期:2018-06-05 发布日期:2018-06-22
通讯作者: 李莉 E-mail:annaleelin@imm.ac.cn
基金资助:
中国医学科学院医学与健康科技创新工程（No.2016-I2M-3-009）资助项目.

Advances in Development of Chiral Sensors

Xiong Fei, Li Li

a Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received:2018-05-20 Revised:2018-06-05 Published:2018-06-22
Supported by:
Project supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (No. 2016-I2M-3-009).

Chiral compounds play an essential role in asymmetric synthesis, biology, medical field and pharmacology. It is necessary to establish fast, sensitive and high enantioselective chiral analysis methods. Chiral sensors, which could determine the absolute configuration and the value of enantiomeric excess of enantiomers, have the advantages of simple, rapid, sensitive and real-time. Herein, the review is focused on the recent progress of chiral fluorescent sensors, circular dichroism sensors, UV-Vis sensors, NMR sensors and MS sensors. Their characteristics, sensing mechanism and applications in chiral recognition are reviewed, and the prospects of chiral sensors are also discussed.

Key words: chiral sensor, chiral compound, chiral recognition, enantiomeric excess, absolute configuration

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Xiong Fei, Li Li. Advances in Development of Chiral Sensors[J]. Chin. J. Org. Chem., 2018, 38(11): 2927-2936.

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手性传感器研究进展

Advances in Development of Chiral Sensors

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