Aniline-Promoted Synthesis of Isobenzofuranone Derivatives

doi:10.6023/cjoc201806035

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 3009-3015.DOI: 10.6023/cjoc201806035 Previous Articles Next Articles

Special Issue: 有机小分子-金属协同催化

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苯胺促进的异苯并呋喃酮类衍生物的合成

袁硕^a,b,c, 王四喜^a, 陈锦杰^a, 赵龙飞^a,b,c, 余斌^a,b,c,d, 刘宏民^a,b,c

a 郑州大学药学院郑州 450001;
b 新药创制与药物安全性评价河南省协同创新中心郑州 450001;
c 教育部药物关键制备技术重点实验室郑州 450001;
d 广东省新药筛选重点实验室广州 510033

收稿日期:2018-06-21 修回日期:2018-07-16 发布日期:2018-07-24
通讯作者: 余斌, 刘宏民 E-mail:zzuyubin@hotmail.com;liuhm@zzu.edu.cn
基金资助:
国家自然科学基金（Nos.81430085，81773562，81703326）、国家重点研发计划（No.2016YFA0501800）、河南省科技攻关项目（No.182102310123）、中国博士后面上基金（No.2018M630840）、广东省新药筛选重点实验室开放课题（No.GDKLNDS-2018OF006）、河南省高等学校重点科研项目（No.18B350009）和郑州大学大学生创新创业训练计划（No.201810459101）资助项目.

Aniline-Promoted Synthesis of Isobenzofuranone Derivatives

Yuan Shuo^a,b,c, Wang Sixi^a, Chen Jinjie^a, Zhao Longfei^a,b,c, Yu Bin^a,b,c,d, Liu Hongmin^a,b,c

a School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001;
b Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001;
c Key Laboratory of Technology of Drug Preparation, Ministry of Education, Zhengzhou 450001;
d Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou 510033

Received:2018-06-21 Revised:2018-07-16 Published:2018-07-24
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81430085, 81773562, 81703326), the National Key Research Program of Proteins (No. 2016YFA0501800), the Scientific Program of Henan Province (No. 182102310123), the China Postdoctoral Science Foundation (No. 2018M630840), the Open Project of Guangdong Provincial Key Laboratory of New Drug Screening (No. GDKLNDS-2018OF006), the Key Research Program of Higher Education of Henan Province (No. 18B350009), and the Undergraduate Innovation and Entrepreneurship Training Program of Zhengzhou University (No. 201810459101).

1. Aniline-Promoted Synthesis of Isobenzofuranone Derivatives.PDF(1087KB)

Abstract

Isobenzofuranone derivatives are widely found in nature and have shown diverse biological activities. In this work, the aniline-promoted synthesis of isobenzofuranone derivatives starting from 2-carboxybenzaldehyde and substituted acetophenones under mild reaction conditions is reported. This method has broad substrate scope, high yields, and is operationally convenient, and therefore could serve as an attractive strategy for practical synthesis of isobenzofuranone derivatives.

Key words: isobenzofuranone derivatives, aniline, cascade reactions

Cite this article

Yuan Shuo, Wang Sixi, Chen Jinjie, Zhao Longfei, Yu Bin, Liu Hongmin. Aniline-Promoted Synthesis of Isobenzofuranone Derivatives[J]. Chin. J. Org. Chem., 2018, 38(11): 3009-3015.

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苯胺促进的异苯并呋喃酮类衍生物的合成

Aniline-Promoted Synthesis of Isobenzofuranone Derivatives

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