Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid

doi:10.6023/cjoc201805052

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 521-526.DOI: 10.6023/cjoc201805052 Previous Articles Next Articles

Notes

聚乙二醇接枝4-二甲氨基吡啶功能化离子液体催化合成吡唑并[1,2-b]酞嗪-5,10-二酮

王英磊^a, 万子娟^b, 罗军^b

a 南阳理工学院生物与化学工程学院南阳 473004;
b 南京理工大学化工学院南京 210094

收稿日期:2018-05-29 修回日期:2018-07-09 发布日期:2018-10-20
通讯作者: 王英磊 E-mail:wangyinglei2014@163.com
基金资助:
国家自然科学基金（No.21002050）、河南省科技攻关项目（No.182102310601）、河南省高等学校重点科研（No.17B150007）资助项目.

Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid

Wang Yinglei^a, Wan Zijuan^b, Luo Jun^b

a School of Biological and Chemical Engineering, Nanyang Institute of Technology, Nanyang 473004;
b School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094

Received:2018-05-29 Revised:2018-07-09 Published:2018-10-20
Contact: 10.6023/cjoc201805052 E-mail:wangyinglei2014@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (No.21002050) the Key Project of Science and Technology of Henan Province (No. 182102310601) and the Key Scientific Research Projects of Henan Province (No. 17B150007).

1. Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid.PDF(1346KB)

Abstract

A novel poly(ethylene glycol) grafted 4-dimethylaminopyridine functionalized ionic liquid ([DMAP-PEG₁₀₀₀-DIL] [BF₄]) was prepared and characterized by ¹H NMR, ¹³C NMR, FT-IR and ESI-MS. In the presence of[DMAP-PEG₁₀₀₀-DIL] [BF₄], various substituted aromatic aldehyde could react with malononitrile (or ethyl cyanoacetate) and phthalhydrazide in water to obtain a series of pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with 85%~96% yields. The mild reaction conditions, high stable and recyclable ionic liquids, environmental friendliness are advantages of this methodology.

Key words: poly(ethylene glycol), ionic liquid, 4-dimethylaminopyridine, pyrazolo[1,2-b]phthalazine-5,10-dione, aqueous media

Cite this article

Wang Yinglei, Wan Zijuan, Luo Jun. Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid[J]. Chin. J. Org. Chem., 2019, 39(2): 521-526.

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聚乙二醇接枝4-二甲氨基吡啶功能化离子液体催化合成吡唑并[1,2-b]酞嗪-5,10-二酮

Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid

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