Chloroamine-T Promoted Three-Component Reaction of Aldehydes, Hydrazines and Fumarate Esters for the Construction of Tetra-substituted Pyrazole Derivatives

doi:10.6023/cjoc201901014

Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (7): 1923-1929.DOI: 10.6023/cjoc201901014 Previous Articles Next Articles

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氯胺-T促进的醛、肼与富马酸酯的三组分反应构建四取代吡唑类化合物

陈樱, 祝家楠, 赵圣印

东华大学化学化工与生物工程学院生态纺织教育部重点实验室上海 201620

收稿日期:2019-01-10 修回日期:2019-03-18 发布日期:2019-04-09
通讯作者: 赵圣印 E-mail:syzhao8@dhu.edu.cn
基金资助:
上海市自然科学基金（No.15ZR1401400）资助项目.

Chloroamine-T Promoted Three-Component Reaction of Aldehydes, Hydrazines and Fumarate Esters for the Construction of Tetra-substituted Pyrazole Derivatives

Chen Ying, Zhu Jianan, Zhao Shengyin

Key Laboratory of Science and Technology of Exo-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620

Received:2019-01-10 Revised:2019-03-18 Published:2019-04-09
Contact: 10.6023/cjoc201901014 E-mail:syzhao8@dhu.edu.cn
Supported by:
Project supported by the Natural Science Foundation of Shanghai City (No. 15ZR1401400).

1. Chloroamine-T Promoted Three-Component Reaction of Aldehydes, Hydrazines and Fumarate Esters for the Construction of Tetra-substituted Pyrazole Derivatives.PDF(511KB)

Abstract

Pyrazoles, a class of five-membered nitrogen-containing heterocyclic compounds, showed antibacterial, anticancer and antioxidative activity, and so on. They also served as important intermediates in organic synthesis. To develop the general and straightforward methods to their synthesis is of great significance. In this paper, a series of tetra-substituted pyrazoles were synthesized from aldehydes, hydrazines and fumarate esters by three-component[3+2] cycloaddition reaction in the presence of chloroamine-T with 60%~87% yields. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS analysis.

Key words: aldehyde, aldehyde, fumarate ester, chloroamine-T, pyrazole

Cite this article

Chen Ying, Zhu Jianan, Zhao Shengyin. Chloroamine-T Promoted Three-Component Reaction of Aldehydes, Hydrazines and Fumarate Esters for the Construction of Tetra-substituted Pyrazole Derivatives[J]. Chinese Journal of Organic Chemistry, 2019, 39(7): 1923-1929.

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氯胺-T促进的醛、肼与富马酸酯的三组分反应构建四取代吡唑类化合物

Chloroamine-T Promoted Three-Component Reaction of Aldehydes, Hydrazines and Fumarate Esters for the Construction of Tetra-substituted Pyrazole Derivatives

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