Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease

doi:10.6023/cjoc201901037

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (9): 2632-2638.DOI: 10.6023/cjoc201901037 Previous Articles Next Articles

ARTICLE

碱性蛋白酶催化合成喹唑啉酮衍生物

谢宗波, 李红霞, 刘联胜, 兰金, 胡智宇, 乐长高

东华理工大学应用化学系南昌 330013

收稿日期:2019-01-24 修回日期:2019-03-27 发布日期:2019-04-11
通讯作者: 谢宗波, 乐长高 E-mail:zbxie@ecit.cn;zhgle@ecit.cn
基金资助:
国家自然科学基金（Nos.21462001，21465002，21262002）、江西省科技计划（No.20161BCB24006）、江西省教育厅科技（Nos.KJLD14050，GJJ150584）资助项目.

Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease

Xie Zongbo, Li Hongxia, Liu Liansheng, Lan Jin, Hu Zhiyu, Le Zhanggao

Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Received:2019-01-24 Revised:2019-03-27 Published:2019-04-11
Contact: 10.6023/cjoc201901037 E-mail:zbxie@ecit.cn;zhgle@ecit.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21465002, 21262002), the Science and Technology Projects of Jiangxi (No. 20161BCB24006), and the Science and Technology Foundation of the Jiangxi Education Department (Nos. KJLD14050, GJJ150584).

1. Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease.PDF(2089KB)

Abstract

Alkaline protease-catalyzed synthesis of quinazolinone derivatives was developed between β-keotester and o-aminobenzamide. Because ethanol is one kind of eco-friendly solvents, this method can reduce the impact of solvents on the environment. Alkaline protease as a biocatalyst has many advantages, e.g. high catalytic activity, environmentally friendly, wide variety of sources and simple operation. In addition, a variety of quinazolinone derivatives was obtained with good to excellent yields just using 2000 U alkaline protease as catalyst.

Key words: quinazolinone derivatives, biocatalysis, alkaline protease, ethanol, promiscuity

Cite this article

Xie Zongbo, Li Hongxia, Liu Liansheng, Lan Jin, Hu Zhiyu, Le Zhanggao. Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease[J]. Chin. J. Org. Chem., 2019, 39(9): 2632-2638.

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碱性蛋白酶催化合成喹唑啉酮衍生物

Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease

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