Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (10): 3118-3128.DOI: 10.6023/cjoc202208043 Previous Articles     Next Articles

Special Issue: 不对称催化专辑



张洁明a, 倪航b, 吴起a, 杨俊锋c,*(), 张俊良c,*()   

  1. a 浙江大学化学系 杭州 310027
    b 浙江省化工研究院有限公司 杭州 310023
    c 复旦大学化学系 上海 200438
  • 收稿日期:2022-08-31 修回日期:2022-10-20 发布日期:2022-11-02
  • 通讯作者: 杨俊锋, 张俊良
  • 基金资助:
    国家重点研发计划(2021YFF0701600); 国家自然科学基金(22031004); 国家自然科学基金(21921003); 国家自然科学基金(91956128); 上海市科学技术委员会(21ZR1445900); 上海市教育委员会(20212308)

Development of P, S and Si-Stereogenic Compounds Synthesis via Palladium Catalysis

Jieming Zhanga, Hang Nib, Qi Wua, Junfeng Yangc(), Junliang Zhangc()   

  1. a Department of Chemistry, Zhejiang University, Hangzhou 310027
    b Zhejiang Research Institute of Chemical Industry, Hangzhou 310023
    c Department of Chemistry, Fudan University, Shanghai 200438
  • Received:2022-08-31 Revised:2022-10-20 Published:2022-11-02
  • Contact: Junfeng Yang, Junliang Zhang
  • Supported by:
    National Key R&D Program of China(2021YFF0701600); National Natural Science Foundation of China(22031004); National Natural Science Foundation of China(21921003); National Natural Science Foundation of China(91956128); Science and Technology Commission of Shanghai Municipality(21ZR1445900); Shanghai Municipal Education Commission(20212308)

Compounds bearing phosphorus, sulfur or silicon stereogenic center have a wide range of applications in the fields of medicine, pesticides, organic synthesis and material science. Efficient construction of these three types of heteroatom-centered chirality has gradually developed as one of the most important frontiers in asymmetric synthetic chemistry. This paper focuses on the recent development of the asymmetric synthesis via palladium/chiral complexes or using the chiral auxiliaries. Strategies such as P—X (X=H, Si or O) bond activation, desymmetrization, and cycloaddition for P-chiral compounds synthesis are introduced, while the methods for S and Si chiral compounds are somewhat similar. The mechanism of some representative examples and their potential applications are also included.

Key words: palladium catalysis, P-chirality, S-chirality, Si-chirality, asymmetric catalysis