Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (12): 4712-4717.DOI: 10.6023/cjoc202111010 Previous Articles Next Articles
Special Issue: 有机电合成虚拟专辑; 绿色合成化学专辑; 热点论文虚拟合集
ARTICLES
收稿日期:
2021-11-04
修回日期:
2021-12-09
发布日期:
2021-12-15
通讯作者:
于贤勇, 曹忠
基金资助:
Hongyu Wua, Xianyong Yub(), Zhong Caoa()
Received:
2021-11-04
Revised:
2021-12-09
Published:
2021-12-15
Contact:
Xianyong Yu, Zhong Cao
Supported by:
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Hongyu Wu, Xianyong Yu, Zhong Cao. Electrochemical Multicomponent Synthesis of α-Ketoamides from α-Oxocarboxylic Acids, Isocyanides and Water[J]. Chinese Journal of Organic Chemistry, 2021, 41(12): 4712-4717.
Entry | Variation from the standard reaction conditions | Yieldb/% |
---|---|---|
1 | None | 86 |
2 | RVC(+)|Al(–) instead of RVC(+)|Pt(–) | 74 |
3 | RVC(+)|Ag(–) instead of RVC(+)|Pt(–) | 78 |
4 | RVC(+)|RVC (–) instead of RVC(+)|Pt(–) | 73 |
5 | Pt(+)|Pt(–) instead of RVC(+)|Pt(–) | 80 |
6 | C(+)|Pt(–) instead of Pt(+)|Pt(–) | 81 |
7 | NH4I instead of KI | 64 |
8 | nBu4NI instead of KI | 79 |
9 | LiBF4 instead of KI | N.R. |
10 | nBu4NBF4 instead of KI | N.R. |
11 | Et4NClO4 instead of KI | N.R. |
12 | LiClO4 instead of KI | N.R. |
13 | KI (10 mol%) instead of KI (20 mol%), 12 h | 23 |
14 | HFIP/H2O instead of MeCN/H2O | 70 |
15 | DMF/H2O instead of MeCN/H2O | 26 |
16 | THF/H2O instead of MeCN/H2O | 21 |
17 | DMSO/H2O instead of MeCN/H2O | Trace |
18 | EtOH/H2O instead of MeCN/H2O | Trace |
19 | DMA/H2O instead of MeCN/H2O | Trace |
20 | MeCN/H2O=8 mL/1 mL | 76 |
21 | MeCN/H2O=8 mL/3 mL | 80 |
22 | 10 mA instead of 6 mA, 12 h | 34 |
23 | 3 mA instead of 6 mA, 12 h | 81 |
24 | No electricity | N.R. |
25 | Under N2 atmosphere | 87 |
Entry | Variation from the standard reaction conditions | Yieldb/% |
---|---|---|
1 | None | 86 |
2 | RVC(+)|Al(–) instead of RVC(+)|Pt(–) | 74 |
3 | RVC(+)|Ag(–) instead of RVC(+)|Pt(–) | 78 |
4 | RVC(+)|RVC (–) instead of RVC(+)|Pt(–) | 73 |
5 | Pt(+)|Pt(–) instead of RVC(+)|Pt(–) | 80 |
6 | C(+)|Pt(–) instead of Pt(+)|Pt(–) | 81 |
7 | NH4I instead of KI | 64 |
8 | nBu4NI instead of KI | 79 |
9 | LiBF4 instead of KI | N.R. |
10 | nBu4NBF4 instead of KI | N.R. |
11 | Et4NClO4 instead of KI | N.R. |
12 | LiClO4 instead of KI | N.R. |
13 | KI (10 mol%) instead of KI (20 mol%), 12 h | 23 |
14 | HFIP/H2O instead of MeCN/H2O | 70 |
15 | DMF/H2O instead of MeCN/H2O | 26 |
16 | THF/H2O instead of MeCN/H2O | 21 |
17 | DMSO/H2O instead of MeCN/H2O | Trace |
18 | EtOH/H2O instead of MeCN/H2O | Trace |
19 | DMA/H2O instead of MeCN/H2O | Trace |
20 | MeCN/H2O=8 mL/1 mL | 76 |
21 | MeCN/H2O=8 mL/3 mL | 80 |
22 | 10 mA instead of 6 mA, 12 h | 34 |
23 | 3 mA instead of 6 mA, 12 h | 81 |
24 | No electricity | N.R. |
25 | Under N2 atmosphere | 87 |
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