Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (6): 1820-1830.DOI: 10.6023/cjoc202201011 Previous Articles     Next Articles

Special Issue: 有机氟化学虚拟合辑

ARTICLES

可见光诱导活化烯烃的芳基氟烷基化反应

李心灵a, 孟卫东a, 徐修华b, 黄焰根a,*()   

  1. a 东华大学化学化工与生物工程学院 生态纺织教育部重点实验室 上海201620
    b 中国科学院上海有机化学研究所 有机氟化学重点实验室 上海 200032
  • 收稿日期:2022-01-10 修回日期:2022-01-29 发布日期:2022-02-17
  • 通讯作者: 黄焰根
  • 基金资助:
    国家自然科学基金(2199121)

Visible Light Induced Arylfluoroalkylation of Activated Alkenes

Xinling Lia, Weidong Menga, Xiuhua Xub, Yan'gen Huanga()   

  1. a Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620
    b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2022-01-10 Revised:2022-01-29 Published:2022-02-17
  • Contact: Yan'gen Huang
  • Supported by:
    National Natural Science Foundation of China(2199121)

Fluorine-containing compounds have a wide range of applications in the fields of biomedicine and materials, and the development of synthetic methodology for fluorine-containing compounds is very important. Using fac-Ir(ppy)3 as catalyst, a wide variety of amides containing fluoroalkyl substituted α-quaternary carbon center were prepared with N-aryl-N-(aryl- sulfonyl)-2-methyl acrylamides as starting materials by visible light induced cascade fluoroalkyl radical addition, aryl migration and desulfonylation. The reaction conditions are mild, and possess good functional group compatibility.

Key words: photocatalysis, fluoroalkylation, aryl migration, desulfonylation, α-quaternary carbon center, amide