Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (3): 1091-1101.DOI: 10.6023/cjoc202211028 Previous Articles     Next Articles

Special Issue: 中国女科学家专辑

ARTICLES

铜催化环状烯烃烯丙位C(sp3)—H磺酰化反应研究

刘春阳a, 李燕a,*(), 张前a,b,*()   

  1. a 东北师范大学化学学院 长春 130024
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 收稿日期:2022-11-24 修回日期:2023-02-16 发布日期:2023-02-27
  • 通讯作者: 李燕, 张前
  • 基金资助:
    国家自然科学基金(22193012); 国家自然科学基金(21831002); 中央高校基本科研业务经费(2412022ZD049)

Copper-Catalyzed Allylic C(sp3)—H Sulfonylation of Cyclic Olefins

Chunyang Liua, Yan Lia(), Qian Zhanga,b()   

  1. a Department of Chemistry, Northeast Normal University, Changchun 130024
    b State key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2022-11-24 Revised:2023-02-16 Published:2023-02-27
  • Contact: Yan Li, Qian Zhang
  • Supported by:
    National Natural Science Foundation of China(22193012); National Natural Science Foundation of China(21831002); Fundamental Research Funds for the Central Universities(2412022ZD049)

A highly efficient copper-catalyzed direct sulfonylation of allylic C(sp3)—H bond was developed using simple cyclic olefins and sodium sulfite as starting materials. A series of allylic sulfone derivatives were synthesized in moderate to good yields under mild conditions. The mechanism study shows that the reaction might involve radical intermediates.

Key words: copper-catalyzed, radicals, allylic C(sp3)—H, sulfonation reaction, allylic sulfone