Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (3): 981-988.DOI: 10.6023/cjoc202310032 Previous Articles Next Articles
Special Issue: 有机氟化学合辑
ARTICLES
周兰a, 何红a, 杨德巧a, 侯中伟a,*(), 王磊a,b,c,*()
收稿日期:
2023-10-31
修回日期:
2023-12-16
发布日期:
2024-04-02
基金资助:
Lan Zhoua, Hong Hea, De-Qiao Yanga, Zhong-Wei Houa(), Lei Wanga,b,c()
Received:
2023-10-31
Revised:
2023-12-16
Published:
2024-04-02
Contact:
*E-mail: zhongwei.hou@tzc.edu.cn; leiwang88@hotmail.com
Supported by:
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Lan Zhou, Hong He, De-Qiao Yang, Zhong-Wei Hou, Lei Wang. Electrochemical Trifluoromethylation/Spirocyclization of N-Benzylacrylamides to Construct Trifluoromethylated 2-Azaspiro[4.5]decanes[J]. Chinese Journal of Organic Chemistry, 2024, 44(3): 981-988.
Entry | Variation from the standard conditions | Yield b/% |
---|---|---|
1 | None | 78 (75)c |
2 | 2 (1 equiv.) | 40 |
3 | MeCN/H2O (V∶V=13∶1) | 70 |
4 | MeCN | 37 |
5 | No KPF6 | 47 |
6 | 15 mA, 1 h | 55 |
7 | 6 mA, 4 h | 44 |
8 | No electricity | 0 |
9 | Me4NBF4 | 68 |
10 | Et4NBF4 | 72 |
11 | nBu4NBF4 | 58 |
12 | nBu4NPF6 | 59 |
13 | LiClO4 | 70 |
14 | 0 ℃ | 67 |
15 | 60 ℃ | 69 |
Entry | Variation from the standard conditions | Yield b/% |
---|---|---|
1 | None | 78 (75)c |
2 | 2 (1 equiv.) | 40 |
3 | MeCN/H2O (V∶V=13∶1) | 70 |
4 | MeCN | 37 |
5 | No KPF6 | 47 |
6 | 15 mA, 1 h | 55 |
7 | 6 mA, 4 h | 44 |
8 | No electricity | 0 |
9 | Me4NBF4 | 68 |
10 | Et4NBF4 | 72 |
11 | nBu4NBF4 | 58 |
12 | nBu4NPF6 | 59 |
13 | LiClO4 | 70 |
14 | 0 ℃ | 67 |
15 | 60 ℃ | 69 |
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