Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (3): 966-971.DOI: 10.6023/cjoc202310029 Previous Articles     Next Articles

ARTICLES

以路易斯碱硼烷为氢供体电催化还原喹啉及酮

陈红斌, 杨思佳, 叶智鹏, 陈凯*(), 向皞月*(), 阳华*()   

  1. 中南大学化学化工学院 长沙 410083
  • 收稿日期:2023-10-30 修回日期:2023-12-28 发布日期:2024-04-02
  • 作者简介:共同第一作者
  • 基金资助:
    国家自然科学基金(22078370); 国家自然科学基金(22078369); 国家自然科学基金(22003077); 国家自然科学基金基础科学中心项目(72088101); 湖南省自然科学基金(2022JJ20055); 湖南省自然科学基金(2020JJ4682)

Electrocatalytic Reduction of Quinolines and Ketones by Using Lewis Base-Ligated Borane as a Hydrogen Donor

Hongbing Chen, Sijia Yang, Zhipeng Ye, Kai Chen(), Haoyue Xiang(), Hua Yang()   

  1. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083
  • Received:2023-10-30 Revised:2023-12-28 Published:2024-04-02
  • Contact: *E-mail: hyangchem@csu.edu.cn; xianghaoyue@csu.edu.cn; kaichen@csu.edu.cn
  • About author:These authors contributed equally to this work.
  • Supported by:
    National Natural Science Foundation of China(22078370); National Natural Science Foundation of China(22078369); National Natural Science Foundation of China(22003077); Basic Science Center Project for National Natural Science Foundation of China(72088101); Natural Science Foundation of Hunan Province(2022JJ20055); Natural Science Foundation of Hunan Province(2020JJ4682)

By employing Lewis base-ligated boranes (LB-BH3) as the hydrogen donor, a general and straightforward electrochemical protocol for transfer hydrogenation of quinoline was developed to access a variety of bioactive 1,2,3,4- tetrahydroquinolines. Moreover, this developed protocol was successfully applied to the reduction of other double bonds, including C=O, N=N and C=C bonds. This method has some characteristics such as simple operation, mild reaction conditions and a wide range of substrates.

Key words: borane, electrochemistry, reduction, 1,2,3,4-tetrahydroquinoline