Sulfuryl Group-Involved Drugs Approved by the Food and Drug Administration (FDA) from 2021 to 2023

doi:10.6023/cjoc202403042

Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (9): 2682-2699.DOI: 10.6023/cjoc202403042 Previous Articles Next Articles

REVIEWS

2021至2023年食品药品监督管理局(FDA)认证的含硫酰基药物

喻志岚^a, 邹志玲^a, 袁志文^a, 曾春玲^b, 彭丽芬^a^,^*(), 许新华^b, 唐子龙^a^,^*(), 刘喜荣^b^,^*()

a 湖南科技大学化学化工学院理论有机化学与功能分子教育部重点实验室精细聚合物可控制备及功能化应用湖南省重点实验室湖南湘潭 411201
b 湖南大学化学化工学院化学生物传感与计量学国家重点实验室长沙 410082

收稿日期:2024-03-26 修回日期:2024-04-27 发布日期:2024-05-23
通讯作者: 彭丽芬, 唐子龙, 刘喜荣
基金资助:
国家自然科学基金(22277025); 国家自然科学基金(21802040); 湖南省湖湘高层次人才聚集工程(创新团队)(2021RC5028); 湖南省自然科学基金(2022JJ80082); 湖南省自然科学基金(2022JJ30240)

Sulfuryl Group-Involved Drugs Approved by the Food and Drug Administration (FDA) from 2021 to 2023

Zhilan Yu^a, Zhiling Zou^a, Zhiwen Yuan^a, Chunling Zeng^b, Lifen Peng^a(), Xinhua Xu^b, Zilong Tang^a(), Xirong Liu^b()

a Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201
b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082

Received:2024-03-26 Revised:2024-04-27 Published:2024-05-23
Contact: Lifen Peng, Zilong Tang, Xirong Liu
Supported by:
National Natural Science Foundation of China(22277025); National Natural Science Foundation of China(21802040); Innovation Team of Huxiang High-Level Talent Gathering Engineering(2021RC5028); Natural Science Fund Project of Hunan Province(2022JJ80082); Natural Science Fund Project of Hunan Province(2022JJ30240)

Organic sulfone compounds, exhibiting interesting bioactivities, were widely applied in the field of pharmaceutical and medicine. And numerous of sulfuryl group-involved drugs were approved by the Food and Drug Administration (FDA). Odevixibat, maralixibat chloride and belzutifan approved in 2021 could be applied in the treatment of progressive familial intrahepatic cholestasis (PFIC), cholestatic pruritus and clear cell renal cell carcinoma (ccRCC), respectively. In 2022, abrocitinib, pyrukynd and voquezna were approved for the treatment of atopic dermatitis, pyruvate kinase deficiency (PKD) and acid-related disorders, respectively. Defencath for preventing bloodstream infections, sparsentan for treatment of proteinuria related to IgA nephropathy, and xacduro for treatment of hospital-acquired bacterial pneumonia (HABP) were approved in 2023. In this review, the synthesis and therapies of these sulfuryl group-involved drugs approved from 2021 to 2023 are discussed in details.

Key words: sulfone, drugs, Food and Drug Administration (FDA) approval

Cite this article

Zhilan Yu, Zhiling Zou, Zhiwen Yuan, Chunling Zeng, Lifen Peng, Xinhua Xu, Zilong Tang, Xirong Liu. Sulfuryl Group-Involved Drugs Approved by the Food and Drug Administration (FDA) from 2021 to 2023[J]. Chinese Journal of Organic Chemistry, 2024, 44(9): 2682-2699.

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Fig. & Tab. 15

Figure 1. Sulfuryl group-involved drugs

Figure 2. Gut-restricted IBAT inhibitors

Scheme 1. Synthesis of odevixibat 7

Scheme 2. Synthesis of maralixibat chloride 8

Scheme 3. Pirnot’s synthetic route for belzutifan 9

Scheme 4. Synthesis of belzutifan 9

Scheme 5. Synthesis of abrocitinib 10

Scheme 6. Synthesis of pyrukynd 11

Scheme 7. Synthesis of voquezna 12

Scheme 8. Synthesis of taurolidine 13 (Dieter)

Scheme 9. Synthesis of taurolidine 13 (Wang)

Scheme 10. Synthesis of sparsentan 14

Figure 3. Other β-lactamase inhibitors approved or undergoing clinical trials (98~103)

Scheme 11. Synthesis of sulbactam 15

Scheme 12. Synthesis of durlobactam 16

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2021至2023年食品药品监督管理局(FDA)认证的含硫酰基药物

Sulfuryl Group-Involved Drugs Approved by the Food and Drug Administration (FDA) from 2021 to 2023

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