Recent Advances in Hydrogen Atom Transfer Induced Selective C(sp3)-H Functionalization of Alkanes

doi:10.6023/cjoc202407027

Abstract

As a highly atom-economical and step-economic strategy, the functionalization of alkane C(sp³)-H bonds to directly convert alkanes into higher value-added chemicals has been a subject of great interest. However, due to the well-known inertness of alkane C(sp³)-H bonds, controlling the chemical selectivity and regioselectivity of non-activated C(sp³)-H bond functionalization poses a significant challenge. Recently, the utilization of hydrogen atom transfer (HAT) for achieving selectivity in C(sp³)-H bond functionalization has attracted renewed attention as a method distinct from traditional transition metal-catalyzed approaches. In this work, we analyze various HAT-mediated non-activated C(sp³)-H bond functionalization methods, categorizing them based on selectivity of functionalization, with a focus on methods that have achieved regioselectivity control. We conclude by summarizing the current limitations of existing methods and outlook the current challenges and future directions in this field.

Key words: hydrogen atom transfer, unactivated C(sp³)-H bond, C(sp³)-H functionalization, regioselectivity, alkane

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Miao Wang, Yahao Huang, Peng Hu. Recent Advances in Hydrogen Atom Transfer Induced Selective C(sp³)-H Functionalization of Alkanes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202407027.

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氢原子转移介导的烷烃C(sp³)-H选择性官能团化研究进展

Recent Advances in Hydrogen Atom Transfer Induced Selective C(sp³)-H Functionalization of Alkanes

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氢原子转移介导的烷烃C(sp3)-H选择性官能团化研究进展