Recent Advances in Photoredox Nickel-Catalyzed Deoxygenative Coupling of Carboxylic Acids

doi:10.6023/cjoc202603006

Chinese Journal of Organic Chemistry

REVIEW

光氧化还原镍催化羧酸脱氧偶联的研究进展

王东平^a,*, 张淯新^a, 魏闪闪^a, 王峰娇^a, 朱丛军^b,*

^a河南工业大学前沿交叉科学与技术学院郑州 450001;
^b河南工业大学化学化工学院郑州 450001

收稿日期:2026-03-05 修回日期:2026-04-06
基金资助:
国家自然科学基金(No. 22401081, 22202060), 河南工业大学博士科研启动基金(No. 2023BS007, 2021BS080), 河南工业大学青年骨干教师项目(No. 21421251)资助项目.

Recent Advances in Photoredox Nickel-Catalyzed Deoxygenative Coupling of Carboxylic Acids

Dongping Wang^a,*, Yuxin Zhang^a, Shanshan Wei^a, Fengjiao Wang^a, Congjun Zhu^b,*

^aCollege of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001;
^bSchool of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001

Received:2026-03-05 Revised:2026-04-06
Contact: *E-mail: caist_wdp@haut.edu.cn (Dongping Wang); CongjunZhu@haut.edu.cn (Congjun Zhu)
Supported by:
National Natural Science Foundation of China (No. 22401081, 22202060), Doctoral Scientific Research Start-up Foundation from Henan University of Technology (No. 2023BS007, 2021BS080), and the Project of Youth Backbone Teachers of Henan University of Technology (No. 21421251).

Photoredox/nickel dual catalysis has emerged as a mild and efficient platform for the direct deoxygenative coupling of carboxylic acids, capitalizing on their inherent abundance and structural diversity to assemble high-value ketone scaffolds. This review summarizes recent advances categorized by the in situ activation of carboxylic acids, including Dimethyl dicarbonate, Boc₂O, and PPh₃, with discussion on progress in substrate scope, reaction design, and mechanistic understanding. These advances highlight the unique reactivity of this dual catalysis platform and point toward future opportunities in sustainable synthesis.

Key words: photoredox, nickel-catalyzed, deoxygenative, carboxylic acids

Cite this article

Dongping Wang, Yuxin Zhang, Shanshan Wei, Fengjiao Wang, Congjun Zhu. Recent Advances in Photoredox Nickel-Catalyzed Deoxygenative Coupling of Carboxylic Acids[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603006.

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光氧化还原镍催化羧酸脱氧偶联的研究进展

Recent Advances in Photoredox Nickel-Catalyzed Deoxygenative Coupling of Carboxylic Acids

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