Visible-Light Photoredox-Catalyzed Reductive Dearomatization of Indoles

doi:10.6023/cjoc202512044

Abstract

This study developed an efficient photoredox catalytic system for the radical reductive dearomatization of indoles. Employing N,N-diisopropylethylamine (DIPEA) as an organic reductant, the reaction proceeds under mild conditions. Both substituted and unsubstituted indoles at the 2-position are well tolerated, affording a series of structurally diverse functionalized indoline derivatives in high yields (up to 99%). This method exhibits good functional group compatibility and broad substrate scope. Furthermore, scale-up experiments and synthetic transformations demonstrate the potential utility of this strategy in practical synthesis.

Key words: photoredox, indole, dearomatization, indoline, radical

Cite this article

Yang Dan, Li Tian-Zhen, Bai Jingyi, Zhang Hong-Hao, Shi Feng. Visible-Light Photoredox-Catalyzed Reductive Dearomatization of Indoles[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512044.

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可见光氧化还原催化吲哚的还原去芳构化反应