Three Undescribed Iridoid Glycosides from Lamiophlomis rotata and Their Anti-inflammatory Activity

doi:10.6023/cjoc202605008

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独一味中三个新的环烯醚萜苷类成分及其抗炎活性

冉艳芳, 黄利, 李洁, 赵丽莲, 郭大乐^*

成都中医药大学药学院成都 611137

收稿日期:2026-05-11 修回日期:2026-06-10
基金资助:
四川省科技计划(No. 2025ZNSFSC0593)资助项目.

Three Undescribed Iridoid Glycosides from Lamiophlomis rotata and Their Anti-inflammatory Activity

Yan-Fang Ran, Li Huang, Jie Li, Li-Lian Zhao, Da-Le Guo^*

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137

Received:2026-05-11 Revised:2026-06-10
Contact: ^*E-mail: guodale@cdutcm.edu.cn
Supported by:
Sichuan Science and Technology Program (No. 2025ZNSFSC0593).

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Abstract

Three new iridoid glycosides were isolated from Lamiophlomis rotata using silica gel, gel Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography. The structures of the new compounds were elucidated through analysis of spectroscopic evidence, including data obtained from high-resolution electrospray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR). The absolute configurations of the three compounds were confirmed by a combination of sugar hydrolysis, derivatization, and ECD calculations. The anti-inflammatory activities of compounds 1-3 were evaluated by measuring nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophages. All these new findings showed significantly inhibited LPS-induced NO production at the concentration of 7.5 μM.

Key words: Lamiophlomis rotata, iridoid glycosides, Anti-inflammatory Activity

Cite this article

Yan-Fang Ran, Li Huang, Jie Li, Li-Lian Zhao, Da-Le Guo. Three Undescribed Iridoid Glycosides from Lamiophlomis rotata and Their Anti-inflammatory Activity[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202605008.

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独一味中三个新的环烯醚萜苷类成分及其抗炎活性

Three Undescribed Iridoid Glycosides from Lamiophlomis rotata and Their Anti-inflammatory Activity

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