Research on Secondary Metabolites and Antibacterial Activity of a Marine-Derived Fungus Talaromyces sp. F017-1-114

doi:10.6023/cjoc202604035

Chinese Journal of Organic Chemistry ›› 2026, Vol. 46 ›› Issue (10): 4008-4015.DOI: 10.6023/cjoc202604035 Previous Articles Next Articles

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海洋来源真菌Talaromyces sp. F017-1-114次级代谢产物与其抗菌活性研究

何勇, 张亚亚, 符霖, 邓璐楠, 陈光英^*(), 黎婉珊^*()

海南师范大学化学与化工学院热带药用资源化学教育部重点实验室热带药用植物化学海南省重点实验室海口 571158

收稿日期:2026-04-23 修回日期:2026-05-24 发布日期:2026-07-14
通讯作者: 陈光英, 黎婉珊
基金资助:
国家自然科学基金(22267006); 海南省自然科学基金(222QN303); 大学生创新创业训练计划(S202511658012)

Research on Secondary Metabolites and Antibacterial Activity of a Marine-Derived Fungus Talaromyces sp. F017-1-114

Yong He, Yaya Zhang, Lin Fu, Lunan Deng, Guangying Chen^*(), Wanshan Li^*()

Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received:2026-04-23 Revised:2026-05-24 Published:2026-07-14
Contact: Guangying Chen, Wanshan Li
Supported by:
National Natural Science Foundation of China(22267006); Hainan Provincial Natural Science Foundation of China(222QN303); Innovation and Entrepreneurship Training Program for College Students(S202511658012)

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Abstract

Chemical investigation on a marine-derived fungus Talaromyces sp. F017-1-114 led to isolation of two new xanthone derivatives [8β-hydroxy-ergochrome D (1) and 4,2'-linked ergochrysin (2)], one new bisabolane-type sesquiterpene (3), and six known polyhydroxanthones [4,4'-linked secalonic acid A (4), 2,4'-linked secalonic acid A (5), 2,2'-linked secalonic acid A (6), (2S,9S,10S,2'S,9'S,10'S)-epi-blennolide H (7), talaronins F (8), degradation of the acid V (9)]. The structures of the new compounds were demonstrated by HR-ESI-MS, extensive NMR investigations, single-crystal X-ray diffraction analysis with Cu Kα radiation, and electronic circular dichroism (ECD) calculations. Among them, compounds 5 and 6 showed moderate antimicrobial activities against Ralstonia solanacearum ATCC11696 with minimum inhibitory concentration (MIC) values of 25 and 12.5 µg/mL, respectively. Compound 3 exhibited weak antibacterial activity against Staphylococcus aureus ATCC25923 with an MIC value of 50 µg/mL.

Key words: Talaromyces sp., marine-derived fungi, xanthones, sesquiterpenes, antibacterial activity

Cite this article

Yong He, Yaya Zhang, Lin Fu, Lunan Deng, Guangying Chen, Wanshan Li. Research on Secondary Metabolites and Antibacterial Activity of a Marine-Derived Fungus Talaromyces sp. F017-1-114[J]. Chinese Journal of Organic Chemistry, 2026, 46(10): 4008-4015.

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Fig. & Tab. 9

References 21

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Position	1^a		2^b
Position	δ_H	δ_C	δ_H	δ_C
1		164.0, C		162.1, C
2	6.59 (brd, 8.3)	111.3, CH	6.61 (d, 8.6)	110.6, CH
3	7.57 (t, 8.3)	141.8, CH	7.44 (d, 8.6)	140.7, CH
4	6.70 (brd, 8.3)	109.1, CH		114.7, C
5	4.13 (d, 10.0)	73.0, CH	3.80 (d, 11.3)	76.8, CH
6	1.68 (s)	33.7, CH	2.32~2.42 (m)	29.4, CH
7	2.06~2.24 (m)	38.1, CH₂	2.70 (dd, 19.2, 6.2), 2.28 (dd, 19.2, 10.6)	36.3, CH₂
8		108.7, C		177.3, C
9		197.7, C		187.2, C
11	1.19 (d, 6.5)	17.9, CH₃	1.10 (d, 6.4)	18.0, CH₃
12		169.7, C		170.3, C
13			3.74 (s)	53.4, CH₃
4a		160.4, C		155.4, C
8a		74.4, C		101.5, C
9a		109.1, C		107.0, C
10a		88.6, C		84.8, C
1'				160.5, C
2'				118.8, C
3'			8.04 (d, 8.6)	142.9, CH
4'			6.67 (d, 8.6)	107.4, CH
5'			4.23 (s)	77.0, CH
6'			2.55~2.59 (m)	32.4, CH
7'			2.58~2.63 (m), 1.97 (dd, 14.6, 4.0)	26.1, CH₂
8'			5.35 (d, 4.0)	78.6, CH
9'				191.5, C
11'			1.23 (d, 7.4)	22.9, CH₃
12'				169.3, C
4a'				157.4, C
8a'				75.2, C
9a'				107.1, C
10a'				80.9, C
1-OH			11.76 (s)
1'-OH			11.41 (s)
8-OH			13.70 (s)

Position	1^a		2^b
Position	δ_H	δ_C	δ_H	δ_C
1		164.0, C		162.1, C
2	6.59 (brd, 8.3)	111.3, CH	6.61 (d, 8.6)	110.6, CH
3	7.57 (t, 8.3)	141.8, CH	7.44 (d, 8.6)	140.7, CH
4	6.70 (brd, 8.3)	109.1, CH		114.7, C
5	4.13 (d, 10.0)	73.0, CH	3.80 (d, 11.3)	76.8, CH
6	1.68 (s)	33.7, CH	2.32~2.42 (m)	29.4, CH
7	2.06~2.24 (m)	38.1, CH₂	2.70 (dd, 19.2, 6.2), 2.28 (dd, 19.2, 10.6)	36.3, CH₂
8		108.7, C		177.3, C
9		197.7, C		187.2, C
11	1.19 (d, 6.5)	17.9, CH₃	1.10 (d, 6.4)	18.0, CH₃
12		169.7, C		170.3, C
13			3.74 (s)	53.4, CH₃
4a		160.4, C		155.4, C
8a		74.4, C		101.5, C
9a		109.1, C		107.0, C
10a		88.6, C		84.8, C
1'				160.5, C
2'				118.8, C
3'			8.04 (d, 8.6)	142.9, CH
4'			6.67 (d, 8.6)	107.4, CH
5'			4.23 (s)	77.0, CH
6'			2.55~2.59 (m)	32.4, CH
7'			2.58~2.63 (m), 1.97 (dd, 14.6, 4.0)	26.1, CH₂
8'			5.35 (d, 4.0)	78.6, CH
9'				191.5, C
11'			1.23 (d, 7.4)	22.9, CH₃
12'				169.3, C
4a'				157.4, C
8a'				75.2, C
9a'				107.1, C
10a'				80.9, C
1-OH			11.76 (s)
1'-OH			11.41 (s)
8-OH			13.70 (s)

Position	δ_H	δ_C	Position	δ_H	δ_C
1α	2.12~2.18 (m)	26.1, CH₂	7		73.2, C
1β	2.49 (dd, 15.7, 4.8)	26.1, CH₂	8	1.62~1.68 (m)	39.1, CH₂
2		130.9, C	9	2.31~2.36 (m)	23.8, CH₂
3	7.00 (d, 5.2)	140.5, CH	10	6.82 (tq, 7.5, 1.5)	143.7, CH
4α	2.14~2.20 (m)	27.5, CH₂	11		128.1, C
4β	2.37~2.44 (m)	27.5, CH₂	12		169.2, C
5	1.65~1.72 (m)	43.6, CH	13		168.4, C
6α	1.26 (dt, 12.5, 5.9)	24.2, CH₂	14	1.17 (s)	23.7, CH₃
6β	1.94~1.99 (m)	24.2, CH₂	15	1.82 (s)	12.4, CH₃

Position	δ_H	δ_C	Position	δ_H	δ_C
1α	2.12~2.18 (m)	26.1, CH₂	7		73.2, C
1β	2.49 (dd, 15.7, 4.8)	26.1, CH₂	8	1.62~1.68 (m)	39.1, CH₂
2		130.9, C	9	2.31~2.36 (m)	23.8, CH₂
3	7.00 (d, 5.2)	140.5, CH	10	6.82 (tq, 7.5, 1.5)	143.7, CH
4α	2.14~2.20 (m)	27.5, CH₂	11		128.1, C
4β	2.37~2.44 (m)	27.5, CH₂	12		169.2, C
5	1.65~1.72 (m)	43.6, CH	13		168.4, C
6α	1.26 (dt, 12.5, 5.9)	24.2, CH₂	14	1.17 (s)	23.7, CH₃
6β	1.94~1.99 (m)	24.2, CH₂	15	1.82 (s)	12.4, CH₃

海洋来源真菌Talaromyces sp. F017-1-114次级代谢产物与其抗菌活性研究

Research on Secondary Metabolites and Antibacterial Activity of a Marine-Derived Fungus Talaromyces sp. F017-1-114

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