纳米酶介导的炎性肠道疾病治疗研究进展★

doi:10.6023/A23040144

化学学报 ›› 2023, Vol. 81 ›› Issue (8): 1043-1051.DOI: 10.6023/A23040144 上一篇下一篇

所属专题：庆祝《化学学报》创刊90周年合辑

综述

纳米酶介导的炎性肠道疾病治疗研究进展^★

陈其文, 张先正^*()

武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室武汉 430072

投稿日期:2023-04-19 发布日期:2023-09-14

作者简介:

陈其文, 武汉大学博士后, 合作导师为张先正教授. 分别于2015年、2018年在西北农林科技大学获得学士及硕士学位; 2021年在武汉大学获得博士学位, 同年在武汉大学进行博士后研究工作. 主要研究方向为构建微生物基活性生物材料用于疾病治疗.

张先正, 武汉大学教授, 1994、1997、2000年相继于武汉大学获学士、硕士和博士学位. 2000年9月~2001年8月新加坡材料研究所Research Associate. 2001年9月~2004年8月美国康奈尔大学博士后. 自2004年9月起在武汉大学化学与分子科学学院任教授, 主要从事生物医用高分子材料的研究.

^★庆祝《化学学报》创刊90周年.

基金资助:
项目受国家重点研发计划(2019YFA0905603); 国家自然科学基金(22135005); 国家自然科学基金(52131302); 国家自然科学基金(51833007); 博士后科学基金(2021TQ0250); 博士后科学基金(2022M712456)

Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases^★

Qiwen Chen, Xianzheng Zhang()

Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072

Received:2023-04-19 Published:2023-09-14
Contact: *E-mail: xz-zhang@whu.edu.cn
About author:
^★Dedicated to the 90th anniversary of Acta Chimica Sinica.
Supported by:
National Key Research and Development Program of China(2019YFA0905603); National Natural Science Foundation of China(22135005); National Natural Science Foundation of China(52131302); National Natural Science Foundation of China(51833007); China Postdoctoral Science Foundation(2021TQ0250); China Postdoctoral Science Foundation(2022M712456)

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摘要/Abstract

近年来, 炎性肠道疾病(Inflammatory bowel diseases, IBD)的发病率越来越高, 给全球的公共健康带来了沉重的负担. 目前, 人们主要使用抗炎药、抗生素、生物抗体及免疫调节剂等药物来抑制炎症反应治疗IBD, 但疗效并不理想. 生物酶具有高效、专一的催化活性, 在炎性疾病诊疗领域引起了广泛的研究兴趣. 但生物酶纯化困难、在生物体内易失活, 限制了其进一步应用. 相比于生物酶, 纳米酶制备简单、结构稳定、类酶催化活性高, 近年来将纳米酶应用于生物医药领域受到了广泛的关注, 如抗癌、抗菌、抗炎等. 本综述总结了近年来纳米酶在IBD治疗方面的研究进展, 重点介绍了所用纳米酶的组成、合成方法、催化特性及治疗机制. 文中进一步讨论了目前用于IBD治疗纳米酶的应用限制, 并对未来用于IBD治疗的纳米酶的构建进行了展望.

关键词: 纳米酶, 催化活性, 抗炎, 肠道炎症

Recently, the increasing morbidity of inflammatory bowel diseases (IBD) has become a threat to public health around the world. At present, anti-inflammatory drugs, antibiotics, biological antibodies, and immunomodulators are widely used to treat IBD through suppressing inflammation response, but the therapeutic effects are not always satisfied. Biological enzymes have highly efficient and specific catalytic activity, which has aroused extensive research interest in diagnosis and treatment of inflammatory diseases. However, bioenzymes are difficult to be purified and are easy to be inactivated within organism, which limits its further applications. Compared with bioenzymes, nanozymes have simple preparation procedure, stable structure and high enzyme-like catalytic activity. Very recently, nanozymes have been widely used in the field of biomedicine, such as anti-cancer, antibacterial, anti-inflammation and so on. In this review, recent research advances of nanozymes for treatment of IBD are summarized by introducing typical studies, focusing on the composition, synthesis methods, catalytic properties and therapeutic mechanisms of the used nanozymes. This review also discusses the limitations of the current application of nanozymes for the treatment of IBD, and the prospect of the future construction of nanozymes for treatment of IBD.

Key words: nanozymes, catalytic activity, anti-inflammation, intestinal inflammation

引用此文

陈其文, 张先正. 纳米酶介导的炎性肠道疾病治疗研究进展^★[J]. 化学学报, 2023, 81(8): 1043-1051.

Qiwen Chen, Xianzheng Zhang. Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases^★[J]. Acta Chimica Sinica, 2023, 81(8): 1043-1051.

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图/表 8

图1. 用于IBD治疗的纳米酶

Figure 1. Nanozymes used for IBD therapy

Nanozymes	Catalytic activity	Anti-inflammation application	Ref.
Pt NPs	SOD, CAT, POD-like	Human Cerebral Cavernous Malformation (CCM) disease	[34]
PVP-IrNPs	CAT, POD-like	Cell protection	[35]
Rh-PEG NDs	SOD, CAT-lile, and •OH, ONOO⁻，•NO scavenging activity	IBD therapy	[36]
Single-atom Fe-N₄	SOD-like, CAT-like	Cell protection	[37]
Mo NPs	N-Acetyl cysteine-like	Anti-tumor cell	[38]
Fe₃O₄ NPs	CAT-like	Anti-aging	[39]
MnO₂ NPs	SOD, CAT-like	Cell protection	[40]
Mn₃O₄ NPs	SOD, CAT, GPx-like, and •OH scavenging activity	Parkinson’s disease	[41]
CeO₂ NPs	SOD, CAT-like	Neuroprotective effect	[42]
MoS₂ NPs	SOD, CAT-like	Osteoarthritis	[43]
Cu_xO NPs	SOD, CAT, and GPx-like	Parkinson’s disease	[44]
CuTA	SOD-like, CAT-like, and •OH scavenging activity	Lung destruction	[45]
NiCo₂O₄@PVP	•OH, $\mathrm{O}_{2}^{-}$ and H₂O₂ scavenging activity	IBD therapy	[46]
PtPdMo trim	POD, CAT-like, and •OH, ¹O₂, •NO scavenging activities	Brain injury	[47]
Carbogenic nanozyme	SOD, CAT-like •NO and ONOO-scavenging activities	Traumatic brain injury	[48]
C-dots nanozyme	SOD-like	IBD therapy	[49]
Melanin NPs	SOD-like	Ischemic stroke	[50]
Se-CQDs	•OH scavenging activity	Cell protection	[51]
Se@Pda	GPx-like	Anti-inflammation	[52]

表1. 用于抗炎应用的经典纳米酶

Table 1. Typical nanozymes for anti-inflammation application

图2. 具有ROS清除活性的Mn3O4纳米酶的构建及用于IBD治疗示意图[70]

Figure 2. Schematic illustration of fabrication of Mn3O4 nanozyme with ROS scavenging activity for IBD therapy. Reprinted with permission from ref. [70]. Copyright (2021) Wiley-VCH

图3. Au/CeO2@HA纳米酶的合成及治疗IBD的示意图[78]

Figure 3. Schematic illustration of the synthesis and IBD therapy of Au/CeO2@HA nanozyme. Reprinted with permission from ref. [78]. Copyright (2023) Elsevier

图4. (A) PPBs的合成流程. (B) PPBs介导的DSS诱导的结肠炎治疗示意图[91]

Figure 4. (A) The synthesis process of PPBs. (B) Schemetic illustration of PPBs-guided DSS-induced colitis therapy. Reprinted with permission from ref. [91]. Copyright (2018) the American Chemical Society

图5. 用于GPx仿生的MIL-47(V) MOF纳米酶的合成及IBD治疗应用[101]

Figure 5. Illustration of the synthesis of GPx-mimicking MIL-47(V) MOF nanozymes and IBD therapy application. Reprinted with permission from ref. [101]. Copyright (2021) Wiley-VCH

图6. Bi2Se3纳米盘制备及用于IBD治疗示意图[114]

Figure 6. Schematic illustration of the preparation of Bi2Se3 nanodiscs and IBD therapy. Reprinted with permission from ref. [114]. Copyright (2023) Elsevier

图7. (A)碳点纳米酶的合成流程及ROS清除性能示意图. (B)碳点纳米酶应用于IBD治疗示意图[49]

Fig 7. (A) Shematic illustration of the synthesis procedure of C-dots nanozyme and its ROS scavenging properties. (B) Schematic illustration of therapy application of C-dots nanozyme for IBD. Reprinted with permission from ref. [49]. Copyright (2023) Elsevier

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纳米酶介导的炎性肠道疾病治疗研究进展^★

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