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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (8): 761-766. 上一篇    下一篇

研究论文

磁性有序介孔炭的制备及药物吸附行为研究

邢 伟 禚淑萍* 司维江 袁 勋

  

  1. (山东理工大学化学工程学院 淄博 255049)

  • 投稿日期:2008-08-08 修回日期:2008-11-28 发布日期:2009-04-28
  • 通讯作者: 禚淑萍

Preparation of Magnetic Ordered Mesoporous Carbon and Its Drug Adsorption Behavior

Xing, Wei Zhuo, Shuping* Si, Wei-Jiang Yuan, Xun   

  1. (School of Chemical Engineering, Shandong University of Technology, Zibo 255049)
  • Received:2008-08-08 Revised:2008-11-28 Published:2009-04-28
  • Contact: Zhuo, Shuping

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被引次数

39 | 7

采用纳米共铸法将磁性纳米粒子包埋到有序介孔炭的骨架中, 制成含有磁性纳米粒子的有序介孔炭(Fe/OMCs). 实验通过氮气吸附、扫描电镜、X射线衍射、磁性测试等手段对Fe/OMCs进行了系统的表征. 研究表明, Fe/OMCs基本保持了有序介孔结构, 磁性粒子在材料中以纳米α-Fe粒子的形式存在, 并且具有超顺磁特性. 盐酸四环素(TH)在Fe/OMCs上的吸附研究表明, Fe/OMCs的介孔表面积和介孔孔容是决定TH吸附量的关键因素. 脱附动力学研究表明, Fe/OMCs的孔尺寸是影响脱附速率的关键因素, 孔径越大, TH的脱附速率就越大.

关键词: 磁性, 铁/碳复合材料, 药物输送, 吸附, 脱附

A co-casting method has been introduced to synthesize Fe/OMC, a kind of mesoporous carbon with iron nanoparticles embedded in the carbon pore-wall. The as-prepared materials were characterized by a variety of techniques such as N2 adsorption, scanning electron microscopy (SEM), X-ray diffraction and vibrating-sample magnetometry (VSM). Results show that the Fe/OMC basically maintains an ordered mesoporous structure. α-Fe nanoparticles exist in the carbon framework and show superparamagnetic behavior. Adsorption isotherms of tetracycline hydrochloride (TH) on the Fe/OMC show that the mesopore surface area and mesopore volume are crucial factors for the drug uptakes. Desorption kinetic studies show that the pore size was vital to the desorption rate of TH. The sample with larger pore size has higher desorption rate of TH.

Key words: magnetic, Fe/carbon composite, drug delivery, adsorption, desorption