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化学学报
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化学学报 ›› 2011, Vol. 69 ›› Issue (22): 2696-2702. 上一篇    下一篇

研究论文

双相识别手性萃取佐匹克隆对映体动力学研究

唐课文*，李洪建，刘永兵   

  1. (湖南理工学院化学化工系 岳阳 414006)
  • 投稿日期:2011-05-11 修回日期:2011-07-11 发布日期:2011-07-11
  • 通讯作者: 唐课文 E-mail:tangkewen@sina.com
  • 基金资助:

    国家自然科学基金;湖南省自然科学杰出青年基金

Determination of Kinetics in Biphasic Recognition Chiral Extraction for Separation of Zopiclone Enantiomers

TANG Ke-Wen, LI Hong-Jian, LIU Yong-Bing   

  1. (Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006)
  • Received:2011-05-11 Revised:2011-07-11 Published:2011-07-11
  • Supported by:

    ;Hunan Provincial Natural Science Foundation of China

PDF

952

被引次数

7

以羟丙基-β-环糊精(HP-β-CD)和L-酒石酸异丁酯(L-IBTA)分别为水相和有机相中手性选择体构成双相识别手性萃取体系, 研究其对佐匹克隆(ZPC)对映体的萃取动力学. 分别考察了搅拌速度、两相接触面积、水相中ZPC对映体浓度、水相及有机相中手性选择体浓度以及水相pH值对ZPC对映体萃取动力学的影响. 结果表明, L-IBTA萃取ZPC对映体的反应为“快反应”|对ZPC对映体反应是一级反应, 对L-IBTA反应是二级反应|对R-ZPC和S-ZPC反应速率常数分别为31.25×10－5和48.74×10－5 mol－2•m6•s－1. 萃取速率随HP-β-CD浓度的增加而降低. 以上研究结果将为手性萃取的工程设计提供参考.

关键词: 双相识别, 反应萃取, 动力学, 路易斯池, 佐匹克隆对映体

Determination of the intrinsic kinetics on biphasic recognition chiral extraction (BRCE) of zopiclone (ZPC) enantiomers was studied. The BREC system was established by adding hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous phase and L-isobutyl tartrate (L-IBTA) in organic phase. Factors affecting the extraction rate such as agitation speed, interfacial area, initial concentration of enantiomers in aqueous phase, concentrations of HP-β-CD and L-IBTA as well as pH of aqueous phase were separately studied. Results show that the kinetics of the extract reaction is fast. The reactions are found to be first order with respect to ZPC enantiomers and second order with respect to L-IBTA with the forward rate constants of 48.74×10－5 mol－2•m6•s－1 for S-ZPC and 31.25×10－5 mol－2•m6•s－1 for R-ZPC, respectively. The initial extraction rates decrease with the increase of HP-β-CD concentration. These data are very essential for design of the extraction progress.

Key words: biphasic recognition, reactive extraction, kinetic, Lewis cell, zopiclone enantiomers