Applications of Hyaluronic Acid Nanomaterials in Fluorescence/Photoacoustic Imaging and Phototherapy

doi:10.6023/A21050219

Acta Chimica Sinica ›› 2021, Vol. 79 ›› Issue (9): 1097-1106.DOI: 10.6023/A21050219 Previous Articles Next Articles

Special Issue: 分子探针、纳米生物学与生命分析化学

Review

透明质酸纳米材料在荧光/光声成像和光疗中的应用

潘立祥^a, 黄艳琴^a^,^*(), 盛况^a, 张瑞^a^,^c, 范曲立^a, 黄维^a^,^b^,^*()

a 南京邮电大学有机电子与信息显示国家重点实验室信息材料与纳米技术研究院南京 210023
b 西北工业大学柔性电子研究院西安 710072
c 东南大学附属中大医院眼科南京 210009

投稿日期:2021-05-17 发布日期:2021-09-17
通讯作者: 黄艳琴, 黄维

作者简介:

潘立祥, 男, 汉族, 1997年出生于江苏, 2019年本科毕业于盐城工学院, 随后加入南京邮电大学黄艳琴课题组攻读硕士学位, 研究方向为基于近红外有机共轭材料的纳米诊疗剂及其生物应用.

黄艳琴, 南京邮电大学教授, 2006年获复旦大学博士学位, 2006年7月起就职于南京邮电大学信息材料与纳米技术研究院. 主要研究方向是有机/聚合物光电材料及其在化学与生物传感、生物成像与诊疗中的应用. 承担和参与国家省部级各类项目6项, 在Biosensors and Bioelectronics、ACS Appl. Mater. & Interfaces、Polymer Chemistry、Langmuir等国际期刊上发表SCI论文30余篇. 2016年获江苏省科学技术奖二等奖, 2009年获江苏省科技进步奖二等奖.

盛况, 男, 汉族, 1996年出生于江苏, 2018年本科毕业于南京工业大学, 随后加入南京邮电大学黄艳琴课题组攻读硕士学位, 研究方向为水溶性共轭材料生物成像和光疗试剂设计、合成与应用.

张瑞, 2001年7月起就职于东南大学附属中大医院, 从事眼科临床与教学工作, 2019年获得东南大学博士学位. 主要研究方向是眼科新型药物研发及激光在眼科的临床应用. 承担和参与国家自然科学基金、有机电子与信息显示国家重点实验室开放研究基金等科研项目.

范曲立, 南京邮电大学教授, 2003年于新加坡国立大学获得博士学位, 2003年至2006年在复旦大学工作, 2006年8月起就职于南京邮电大学. 主要研究方向是面向纳米生物医学领域有机半导体材料的制备与临床前的应用研究, 近五年来以第一或通讯作者在Nature Communications、 Journal of the American Chemical Society、 Advanced Materials、 ACS Nano 等国际期刊发表SCI论文80余篇; 承担和参与国家省部级各类项目10余项, 2012年获国家优秀青年科学基金, 2013年获国家自然科学二等奖(排名第四), 2014年入选国家百千万人才工程, 2019年入选国家万人计划中青年科技创新领军人才.

黄维, 教授, 博导, 有机电子、塑料电子、印刷电子、生物电子及柔性电子学家, 中国科学院院士、俄罗斯科学院外籍院士、亚太材料科学院院士、东盟工程与技术科学院外籍院士、巴基斯坦科学院外籍院士. 历任复旦大学先进材料研究院院长, 南京邮电大学副校长、党委常委, 南京工业大学校长、党委副书记, 2017任西北工业大学党委常委、常务副校长. 曾两次获得国家自然科学奖二等奖、三次获得高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖、多次获得江苏省科学技术奖一等奖和二等奖, 以及何梁何利基金“科学与技术进步奖”.

基金资助:
教育部创新团队(IRT1148); 验室开放研究基金资助课题资助; 先进生物与化学制造国家协同创新中心及有机电子与信息显示国家重点实; 验室开放研究基金资助课题资助

Applications of Hyaluronic Acid Nanomaterials in Fluorescence/Photoacoustic Imaging and Phototherapy

Lixiang Pan^a, Yanqin Huang^a(), Kuang Sheng^a, Rui Zhang^a^,^c, Quli Fan^a, Wei Huang^a^,^b()

a State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
b Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), Xi'an 710072, China
c Department of Ophthalmology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Received:2021-05-17 Published:2021-09-17
Contact: Yanqin Huang, Wei Huang
Supported by:
Ministry of Education of China(IRT1148); Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM); open research fund of State Key Laboratory of Organic Electronics and Information Displays

The biomedical applications of fluorescence/photoacoustic imaging and phototherapy have attracted more and more attention. However, many fluorescent/photoacoustic contrast agents have some common problems, such as poor biocompatibility, lack of tumor targeting, low signal-to-noise ratio, single function and so on, which seriously limit their application in diagnosis and treatment. Hyaluronic acid (HA) exhibits excellent biocompatibility and active tumor targeting, can be degraded by hyaluronidase, and is easy to be chemically modified and realize the cooperation of a variety of supramolecular weak interactions. Therefore, HA has been combined with fluorescent/photoacoustic contrast agents to prepare nanomaterials, which greatly improves the labeling performance and therapeutic effects in cells and even in vivo. In this paper, the preparation methods of nanomaterials by combining these two kinds of materials are reviewed, and the relationships between the structure and performance of nanomaterials are emphasized, which provides guidance for their future design and development. Finally, the main problems and important research directions in the future are analyzed and prospected.

Key words: hyaluronic acid, fluorescence imaging, photoacoustic imaging, photothermal therapy, photodynamic therapy

Cite this article

Lixiang Pan, Yanqin Huang, Kuang Sheng, Rui Zhang, Quli Fan, Wei Huang. Applications of Hyaluronic Acid Nanomaterials in Fluorescence/Photoacoustic Imaging and Phototherapy[J]. Acta Chimica Sinica, 2021, 79(9): 1097-1106.

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Fig. & Tab. 19

Figure 1. (a) Chemical structure of HA and its principal site for chemical modification. Reaction schemes show chemical modification of HA using (b) carboxylic acid group, (c) hydroxyl group, and (d) reducing end group[29]

Figure 2. Structures of (a) HA-BODIPY and (b) DBHA[31⇓-33]

Figure 6. (a) Synthesis path of HA-cysteamine polymer; (b) schematic diagram of HA-cysteamine polymer-encapsulated quantum dots; (c) TEM image of HA-QD [38], Copyright 2014, Springer Science Business Media Dordrecht

Figure 7. (a) Fluorescence and transmission microscope images of HA-QD and QD near the subcutaneous injection sites; (b) fluorescence and transmission microscope images taken 30 min and 1 d after injection of HA-QD; (c) enlarged fluorescence image taken 1 d after injection of HA-QD [34], Copyright 2009, American Chemical Society

Figure 9. Intracellular ROS was generated in macrophage cells upon LPS stimulation, and the green fluorescence recovery from HFAuNPs was monitored. Hoechst 33628 (blue) was used for staining the nucleus of cells[42], Copyright 2009, Wiley-VCH

Figure 10. In vivo photothermal therapy of SCC7 tumor-bearing mice. (a) Thermal images; (b) temperature changes in tumor area at different time points; (c) SCC7 tumor growth rate; (d) body weight curves[45], Copyright 2014, American Chemical Society

Figure 11. FL imaging of normal nude mice (a) and model mice (b) after intravenous injection of HA-UCNPs, and model mice (c) after intravenous injection of DEG-UCNPs[46], Copyright 2013, American Chemical Society

Figure 12. (A) PET imaging, (B) NIR fluorescence imaging, (C) ultrasound (top) and photoacoustic imaging (bottom) of SCC7 tumor-bearing mice; (D) quantitative analysis of the intensity of all imaging modes at the tumor site over time[55], Copyright 2012, American Chemical Society

Figure 13. (a) Schematic illustration of the overall strategy for HAase detection, fluorescence cell imaging and controlled DOX release; (b) chemical structures of HA-Dox and PFEP[40], Copyright 2015, American Chemical Society

Figure 16. (A) Preparation of PFOB@IR825-HA-Cy5.5 nanoparticles; (B) schematic diagram of the nanocomposite used for photothermal tumor ablation guided by NIRFL/PA/CT trimodal imaging[63], Copyright 2017, Elsevier Ltd.

Figure 17. (a) In vivo PA imaging of blood vessels in the tumor sites were captured at different time points after intravenous injection of IHANPT, HANPT, free ICG, and HANP; (b) photoacoustic intensity of tumor tissues at different time points[69], Copyright 2016, American Chemical Society

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透明质酸纳米材料在荧光/光声成像和光疗中的应用

Applications of Hyaluronic Acid Nanomaterials in Fluorescence/Photoacoustic Imaging and Phototherapy

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