The effect of heavy water on phase transfer catalytic N-alkylation of imidazole and its derivatives

Acta Chimica Sinica ›› 1987, Vol. 45 ›› Issue (8): 791-793. Previous Articles Next Articles

Original Articles

重水在咪唑N-烷基化相转移催化反应中的影响

刘汉明;袁承业

中国科学院上海有机化学研究所

发布日期:1987-08-15

The effect of heavy water on phase transfer catalytic N-alkylation of imidazole and its derivatives

LIU HANMING;YUAN CHENGYE

Published:1987-08-15

Abstract

The effect of heavy water on N-alkylation of imidazole and its derivatives under phase transfer catalytic condition was discussed. It is demonstrated that heavy water shows significant solvent isotope effect, associated with the increase of basicity of imidazole and pyrazole. The reaction rate of N-n-butylation in PTC in H2O and D2O were determine

Key words: IMIDAZOLE P, REACTION MECHANISM, HEAVY WATER, CONCENTRATION, ALKYLATION, ACTIVATION ENERGY, REACTION RATE CONSTANT, N-ALKYL GROUP, WATER PHASE, PHASE TRANSFER CATALYSIS

CLC Number:

O621
O643

Cite this article

LIU HANMING;YUAN CHENGYE. The effect of heavy water on phase transfer catalytic N-alkylation of imidazole and its derivatives[J]. Acta Chimica Sinica, 1987, 45(8): 791-793.

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重水在咪唑N-烷基化相转移催化反应中的影响

The effect of heavy water on phase transfer catalytic N-alkylation of imidazole and its derivatives

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