有机化学 ›› 2016, Vol. 36 ›› Issue (11): 2715-2722.DOI: 10.6023/cjoc201605032 上一篇    下一篇

研究论文

铜促进硫代色酮类化合物的合成研究

李明, 宁加彬, 于乐, 文丽荣   

  1. 青岛科技大学化学与分子工程学院 生态化工国家重点实验室培育基地 青岛 266042
  • 收稿日期:2016-05-17 修回日期:2016-06-12 发布日期:2016-07-07
  • 通讯作者: 文丽荣 E-mail:wenlirong@qust.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21572110,21372137)和山东省自然科学基金(No.ZR2014BM006)资助项目.

Copper-Promoted Synthesis of Thiochromones Derivatives

Li Ming, Ning Jiabin, Yu Le, Wen Lirong   

  1. State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042
  • Received:2016-05-17 Revised:2016-06-12 Published:2016-07-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21572110,21372137) and the Natural Science Foundation of Shandong Province (No.ZR2014BM006).

基于底物设计的概念,建立了一种以β-羰基二硫代羧酸酯和取代邻溴代苯乙酮为合成子,在碘化亚铜/邻菲罗啉促进下高化学选择性地合成硫代色酮类衍生物的新方法.该方法高效、简便且收率高.

关键词: 硫代色酮, β-羰基二硫代羧酸酯, 取代邻溴苯乙酮, 铜, Ullmann偶联反应, 合成

A new methodology to high chemoselectively synthesize thiochromone derivatives from β-oxodithioesters and substituted o-bromoacetophenones promoted by CuI/1,10-phen system based on the substrate-design concept has been developed. This approach has advantages of simple and efficient operation, and high yields.

Key words: thiochromones, β-oxodithioesters, substituted o-bromoacetophenones, copper, Ullmann coupling reaction, synthesis