有机化学 ›› 2018, Vol. 38 ›› Issue (2): 304-315.DOI: 10.6023/cjoc201707002 上一篇    下一篇

综述与进展

卤代苯腈硫解反应规律的研究进展

李闪闪, 洪海龙, 韩利民, 张田苗, 王云龙, 竺宁   

  1. 内蒙古工业大学化工学院 呼和浩特 010051
  • 收稿日期:2017-07-03 修回日期:2017-09-23 出版日期:2018-02-25 发布日期:2017-10-20
  • 通讯作者: 洪海龙, 竺宁 E-mail:honghailong_1979@163.com;zhuning2622@yahoo.com
  • 基金资助:

    国家自然科学基金(No.21362019)、内蒙自然科学基金(No.2016MS0207)和中国科学院“西部之光”人才培养计划项目.

Research Progress for the Thiolysis Reaction of Halobenzonitrile

Li Shanshan, Hong Hailong, Han Limin, Zhang Tianmiao, Wang Yunlong, Zhu Ning   

  1. Chemical Engineering College, Inner Mongolia University of Technology, Hohhot 010051
  • Received:2017-07-03 Revised:2017-09-23 Online:2018-02-25 Published:2017-10-20
  • Contact: 10.6023/cjoc201707002 E-mail:honghailong_1979@163.com;zhuning2622@yahoo.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21362019), the Natural Science Foundation of Inner Mongolia (No. 2016MS0207) and the "Light of West China" Program of Chinese Academy of Sciences.

卤代苯腈是医药、农药、材料等领域的重要原料,含有腈基与卤素两个可与亲核试剂反应的活性位点.本文总结了卤代苯腈与不同硫化物反应合成卤代硫代苯甲酰胺或巯基苯腈的规律,发现在酸性条件下主要生成卤代硫代苯甲酰胺,在碱性条件下主要生成巯基苯腈.

关键词: 硫属, 杂原子化合物, 合成方法, 卤代苯腈, 卤代硫代苯甲酰胺, 巯基苯腈

Halobenzonitrile is an important raw material in the fields of medicine, pesticide and materials. Halobenzonitrile has a nitrile group and a halo group which all could react with nucleophile reagents. The law for the selective synthesis of halothiobenzamide or mercaptobenzonitrile from the reaction of halobenzonitrile and different sulfur source is summarized. It is found that the halothiobenzamide product could be synthesized under protonic acid condition from halobenzonitrile, while the mercaptobenzonitrile product would be formed under the alkaline conditions.

Key words: chalcogens, heteroatom compounds, synthetic methods, halobenzonitrile, halothiobenzamide, mercaptobenzonitrile