有机化学 ›› 2019, Vol. 39 ›› Issue (7): 2094-2098.DOI: 10.6023/cjoc201901010 上一篇    下一篇

研究简报

(±)-Parvistemonine A的全合成

马开庆a, 任虎斌a,b, 吴晓晓a, 钞建斌c, 秦雪梅a   

  1. a 山西大学中医药现代研究中心 太原 030006;
    b 山西大学化学化工学院 太原 030006;
    c 山西大学大型仪器中心 太原 030006
  • 收稿日期:2019-01-07 修回日期:2019-02-12 出版日期:2019-07-25 发布日期:2019-03-08
  • 通讯作者: 马开庆 E-mail:makaiqing@sxu.edu.cn
  • 基金资助:

    山西省回国留学人员科研资助基金(No.2015-020)和山西省高等学校科技创新基金(No.2016115)资助项目.

Total Synthesis of Racemic (±)-Parvistemonine A

Ma Kaiqinga, Ren Hubina,b, Wu Xiaoxiaoa, Chao Jianbinc, Qin Xuemeia   

  1. a Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006;
    b College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006;
    c Scientific Instrument Center, Shanxi University, Taiyuan 030006
  • Received:2019-01-07 Revised:2019-02-12 Online:2019-07-25 Published:2019-03-08
  • Contact: 10.6023/cjoc201901010 E-mail:makaiqing@sxu.edu.cn
  • Supported by:

    Project supported by the Shanxi Scholarship Council of China (No. 2015-020) and the Science and Technology Innovation Project of Shanxi Province (No. 2016115).

Parvistemonine A为从对叶百部中分离得的百部生物碱.以化合物7为原料,通过路易斯酸催化的傅克及内酯化的串联反应,Vilsmeier-Haack及Julia-Kocienski烯烃化等6步反应首次完成了百部生物碱(±)-parvistemonine A的全合成工作,为parvistemonine A衍生物的合成和及其生物活性研究打下基础.

关键词: 天然产物, 百部生物碱, parvistemonine A, 化学合成

Parvistemonine A was isolated from Stemona parviflora. The total synthesis of racemic parvistemonine A was completed in 6 steps for the first time, employing compound 7 as the starting material. The synthetic strategy features a tandem Friedel-Crafts cyclization and lactonization, Vilsmeier-Haack and Julia-Kocienski olefination. This study laid the foundation for the synthesis of the parvistemonine A derivative and its biological activity research.

Key words: natural product, stemona alkaloids, parvistemonine A, chemical synthesis