有机化学 ›› 2019, Vol. 39 ›› Issue (7): 1811-1830.DOI: 10.6023/cjoc201902019 上一篇    下一篇

所属专题: 碳氢活化合辑2018-2019

综述与进展

N-苯氧基乙酰胺导向的碳氢键官能团化反应研究进展

姜晓蕾, 郝佳奇, 周国庆, 侯程程, 胡芳东   

  1. 临沂大学化学化工学院 临沂 276000
  • 收稿日期:2019-02-19 修回日期:2019-03-14 出版日期:2019-07-25 发布日期:2019-04-11
  • 通讯作者: 胡芳东 E-mail:hufangdong@lyu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21801109)、山东省自然科学基金(No.ZR2018BB019)、山东省高等学校科技计划(No.J17KA099)资助项目.

Recent Advances in N-Phenoxyacetamides Directed C-H Bond Functionalizations

Jiang Xiaolei, Hao Jiaqi, Zhou Guoqing, Hou Chengcheng, Hu Fangdong   

  1. School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000
  • Received:2019-02-19 Revised:2019-03-14 Online:2019-07-25 Published:2019-04-11
  • Contact: 10.6023/cjoc201902019 E-mail:hufangdong@lyu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21801109), the Natural Science Foundation of Shandong Province (No. ZR2018BB019), and the Higher Educational Science and Technology Program of Shandong Province (No. J17KA099).

碳氢键活化反应因具有原子经济性和步骤简捷性的特点,近年来成为有机化学研究的热点领域之一.在传统的碳氢键活化反应中,通常需要加入等物质的量的氧化剂来实现催化剂的再生,使催化循环顺利地发生.而N-苯氧基乙酰胺作为一种新型的含有氧化型导向基的反应底物,可以有效地避免等物质的量外加氧化剂的使用,使碳氢键活化在氧化还原中性的条件下进行.综述了N-苯氧基乙酰胺在有机合成领域特别是碳氢键活化反应中的最新研究进展,并对反应的机理进行了讨论.

关键词: N-苯氧基乙酰胺, 内氧化剂, C-H键活化, 偶联组分

The C-H bond activation has become one of the hot fields of organic chemistry in recent years due to its atom economy and step simplicity. In the conventional C-H bond activations, an equivalent amount of oxidants is usually added to regenerate the catalyst and allow the catalytic cycle proceed smoothly. N-Phenoxyacetamide, as a novel reaction substrate containing an oxidizing directing group, can effectively avoid the use of an equivalent external oxidants. Thus, the C-H activation could be conducted under redox neutral conditions. In this paper, the latest research progress of N-phenoxyacetamides in the field of organic synthesis, especially C-H bond activations is reviewed, and the mechanism of the reaction is discussed.

Key words: N-phenoxyacetamides, internal oxidant, C-H bond activation, coupling partners