有机化学 ›› 2017, Vol. 37 ›› Issue (11): 2873-2882.DOI: 10.6023/cjoc201705018 上一篇    下一篇

综述与进展

N-卤代琥珀酰亚胺参与的过渡金属催化芳基C—H键卤化反应研究进展

骆钧飞, 徐星, 赵延超, 梁洪泽   

  1. 宁波大学材料科学与化学工程学院 宁波 315211
  • 收稿日期:2017-05-11 修回日期:2017-06-19 发布日期:2017-07-07
  • 通讯作者: 骆钧飞 E-mail:luojunfei@nbu.edu.cn
  • 基金资助:

    宁波大学人才引进基金(No.ZX2016000748)及宁波大学王宽诚幸福基金资助项目.

Advance of N-Halosuccinimides in Transition-Metal-Catalyzed Halogenation of Aromatic C-H Bonds

Luo Junfei, Xu Xing, Zhao Yanchao, Liang Hongze   

  1. School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211
  • Received:2017-05-11 Revised:2017-06-19 Published:2017-07-07
  • Contact: 10.6023/cjoc201705018 E-mail:luojunfei@nbu.edu.cn
  • Supported by:

    Project supported by the Research Funds of Ningbo University (No. ZX2016000706) and the K. C. Wong Magna Fund in Ningbo University.

卤化反应是有机合成中一种强有力的工具.近年来,过渡金属催化的C-H键的卤化反应已经成为合成有机卤化物的重要方法之一.综述了以N-卤代琥珀酰亚胺为卤源,根据过渡金属类型的不同探讨其催化芳香环C-H键卤化的研究进展,对底物适应范围和反应机理等进行了详细论述,并就该领域的局限性和未来的发展前景进行了总结和展望.

关键词: N-卤代琥珀酰亚胺, C-X键, C-H键活化, 过渡金属催化

Carbon-halogen (C-X) bonds are amongst the most fundamental groups in organic synthesis, which are frequently and widely employed in the synthesis of numerous organic products. The generation of C-X bond, therefore, constitutes an issue of high interest. Herein, the research advances on the transition-metal-catalyzed C-X (X=Cl, Br, I) bond formation via direct C-H bond of aromatic compounds transformation by the use of N-halosuccinimide (NXS) is reviewed.

Key words: N-halosuccinimide, C-X bond, C-H bond activation, transition-metal catalysis