有机化学 ›› 2020, Vol. 40 ›› Issue (1): 15-27.DOI: 10.6023/cjoc201906007 上一篇    下一篇

综述与进展

多取代吡唑合成最新研究进展

王少华a,b,c, 张帮红c, 陈洁a,b, 郑莹莹a,b, 冯娜a,b, 马爱军a,b, 徐学涛a,b, Abdullah M. Asirid   

  1. a 五邑大学生物科技与大健康学院 广东江门 529020;
    b 江门市大健康国际创新研究院 广东江门 529020;
    c 兰州大学药学院 兰州 730000;
    d Faculty of Science, King Abdulaziz University, Jeddah 999088
  • 收稿日期:2019-06-06 修回日期:2019-09-01 出版日期:2020-01-25 发布日期:2019-09-05
  • 通讯作者: 马爱军, 徐学涛 E-mail:maaijun@wyu.edu.cn;xuetaoxu@wyu.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.21472077,21772071)、广东省教育厅基金(Nos.2017KTSCX185,2017KSYS010,2016KCXTD005)、五邑大学高层次人才科研启动(Nos.2018AL002,2018AL003)资助项目.

Recent Progress in Synthesis of Polysubstituted Pyrazoles

Wang Shaohuaa,b,c, Zhang Banghongc, Chen Jiea,b, Zheng Yingyinga,b, Feng Naa,b, Ma Aijuna,b, Xu Xuetaoa,b, Abdullah M. Asirid   

  1. a School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020;
    b International Healthcare Innovation Institute, Jiangmen, Guangdong 529000;
    c School of Pharmacy, Lanzhou University, Lanzhou 730000;
    d Faculty of Science, King Abdulaziz University, Jeddah 999088
  • Received:2019-06-06 Revised:2019-09-01 Online:2020-01-25 Published:2019-09-05
  • Supported by:
    Project supported by the the National Natural Science Foundation of China (Nos. 21472077, 21772071), the Department of Education of Guangdong Province (Nos. 2017KTSCX185, 2017KSYS010, 2016KCXTD005), and the High-level Talent Research Start-up Project of Wuyi University (Nos. 2018AL002, 2018AL003).

吡唑是一类重要的五元含氮杂环化合物,广泛存在于许多天然产物、生物活性分子和药物分子中,而且是一类重要的有机合成中间体.因此,近年来吡唑及其衍生物的合成引起了科学家们的极大兴趣,并得以迅速发展.对近年来多取代吡唑的合成新方法进行了综述,以期对相关领域的研究起到一定的辅助与推动作用.

关键词: 吡唑, 合成, 研究进展

Pyrazole, an important class of nitrogen-containing five-member hetrocyclic compounds, widely exists in natural products, bio-active molecules and drugs, and it is also a valuable intermediate in organic synthesis. The synthesis of polysubstituted pyrazoles has attracted much attention and developed rapidly in recent years. Herein, the recent research progress in the construction of polysubstituted pyrazoles is summarized.

Key words: pyrazole, synthesis, research process