有机化学 ›› 2020, Vol. 40 ›› Issue (1): 28-39.DOI: 10.6023/cjoc201906023 上一篇    下一篇

综述与进展

原位生成的高价碘试剂在有机合成中的应用进展

杨柳a, 许国贺a, 马晶军a, 杨倩b, 冯安a, 崔景港a   

  1. a 河北农业大学渤海校区理工学院 河北黄骅 061100;
    b 河北农业大学动物医学院 河北保定 071000
  • 收稿日期:2019-06-19 修回日期:2019-08-27 出版日期:2020-01-25 发布日期:2019-09-12
  • 通讯作者: 马晶军 E-mail:mjjwjpmartin@163.com
  • 基金资助:
    河北省高等学校青年拔尖人才计划(No.BJ201702)和河北农业大学引进博士专项(No.ZD2016027)资助项目.

Recent Advances in the Application of in-situ Generated Hypervalent Iodine Reagents in Organic Synthesis

Yang Liua, Xu Guohea, Ma Jingjuna, Yang Qianb, Feng Ana, Cui Jingganga   

  1. a College of Science & Technoloy, Agricultural University of Hebei Bohai Campus, Huanghua, Hebei 061100;
    b College of Veterinary Medicine, Hebei Agricultural University, Baoding, Hebei 071001
  • Received:2019-06-19 Revised:2019-08-27 Online:2020-01-25 Published:2019-09-12
  • Supported by:
    Project supported by the Young Tip-Top Talents Plan of Universities and Colleges in Hebei Province (No. BJ201702), and the Specific Foundation for Doctor in Hebei Agriculture University of China (No. ZD2016027).

原位生成的高价碘试剂具有原子经济性、性能温和和绿色环保等优点,在诸多合成和不对称催化等反应中表现活跃.详细介绍了原位生成高价碘的概念以及反应机理,根据不同的反应类型分别对原位生成的三价碘、五价碘以及手性高价碘试剂在有机合成反应中的应用进行了归纳总结,分析了原位生成的高价碘试剂目前面临的问题,并对今后的发展趋势作了展望.

关键词: 原位生成, 高价碘试剂, 合成反应

Based on the atomic economy, mild performance and environment friendly, the in-situ generation of hypervalent iodine reagents has been vastly applied in many significant oxidative reactions and asymmetric catalysis. In this paper, the progress of in-situ generated hypervalent iodine reagents is systematically reviewed, including conception and mechanisms. According to the different reaction types, the application of in-situ generated hapervalent iodine reagent in organic synthesis reaction is summarized, including trivalent iodine reagent, pentavalent iodine reagent and chiral hypervalent iodine reagent. The problem of in-situ generated hapervalent iodine researches is analyzed, and the future development of in-situ hapervalent iodine is prospected.

Key words: in-situ generation, hypervalent iodine reagent, organic synthesis