有机化学 ›› 2016, Vol. 36 ›› Issue (7): 1501-1512.DOI: 10.6023/cjoc201601027 上一篇    下一篇

综述与进展

α,β-不饱和羰基化合物的不对称Diels-Alder反应研究进展

刘文香a,b, 吴宇强a,b, 李灵芝b,c, 李霞b,c   

  1. a. 天津医科大学药学院 天津 300070;
    b. 武警后勤学院药物化学教研室 天津 300309;
    c. 天津市职业与环境危害防制重点实验室 天津 300309
  • 收稿日期:2016-01-20 修回日期:2016-03-01 发布日期:2016-03-28
  • 通讯作者: 李霞 E-mail:lixiazzu@163.com
  • 基金资助:

    武警后勤学院博士启动基金(No.WHB201506)和武警后勤学院创新团队科学基金(No.WHTD201303)资助项目.

Progress on the Asymmetric Diels-Alder Reaction of α,β-Unsaturated Carbonyl Compounds

Liu Wenxianga,b, Wu Yuqianga,b, Li Lingzhib,c, Li Xiab,c   

  1. a. Pharmaceutial College, Tianjin Medical University, Tianjin 300070;
    b. Department of Pharmaceutical Chemistry, Logistic University of PAP, Tianjin 300309;
    c. Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental Hazards, Tianjin 300309
  • Received:2016-01-20 Revised:2016-03-01 Published:2016-03-28
  • Supported by:

    Project supported by the Doctoral Operation Foundation of Medical College of PAP (No. WHB201506) and the Innovative Research Team Program for Scienec and Technology in Logistics University of PAP (No. WHTD201303).

Diels-Alder反应是典型的[4+2]环合反应,自被发现以来备受化学家们的重视. 不对称Diels-Alder反应是合成手性中间体的有效手段,在手性药物和天然产物全合成中得到广泛应用. αβ-不饱和羰基化合物是有机合成反应的关键中间体,根据其结构特点和催化体系类型,分类阐述了αβ-不饱和羰基化合物为亲双烯体的不对称正电子需求Diels-Alder反应的研究进展.

关键词: 不对称Diels-Alder反应, 天然产物, 有机合成反应, α,β-不饱和羰基化合物

Diels-Alder reaction is a [4+2] concerted cycloaddition reaction, which has attracted considerable attention since its discovery. Asymmetric Diels-Alder reaction is an effective method for synthesis of chiral intermediates, so it was widely applied in the total synthesis of drugs and natural products. α,β-Unsaturated carbonyl compounds are a kind of highly reactive versatile intermediates in organic synthesis, according to its structural characteristics and catalytic types, recent advances in asymmetric normal electron-demand Diels-Alder reaction of α,β-unsaturated carbonyl compounds are reviewed in this paper.

Key words: asymmetric Diels-Alder reaction, natural product, organic synthesis, α,β-unsaturated carbonyl compounds